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Information Journal Paper

Title

The Impact of Calcium Hydroxide on the Osteoinductive Capacity of Demineralized Freeze-Dried Bone Allograft: an In-Vitro Study

Pages

  19-27

Abstract

 Statement of the Problem: A great challenge in periodontal therapy is the regen-eration enhancement of osseous defects through applying osteoinductive materials. Demineralized freeze-dried bone allograft (DFDBA) has already been introduced as an allograft with osteoconductive and variable osteoinductive properties. Calci-um hydroxide [Ca(OH)2] is an available well-known material in dentistry, which induces hard tissue formation. Purpose: This study evaluated the efficiency of combination of DFDBA and Ca(OH)2 in improving the quality of osteoinduction of DFDBA. Materials and Method: Human bone marrow-derived mesenchymal Stem Cells were taken from volunteers’ iliac crest. Cell proliferation was determined by MTT test at 18, 24 and 48 hours post-culture in 10 groups. The employed material were 0. 5, 1. 0 mg/ml Ca(OH)2 in two forms of suspension and pH-adjusted solution, 10mg/ml DFDBA per se and in combination with 0. 5 and 1. 0 mg/ml Ca(OH)2. Mineralization was assessed by Alizarin red staining in 10 mg/ml DFDBA, DFDBA+ 0. 5 and 1 mg/ml Ca(OH)2 in solution and suspension forms. The data were statistically analyzed by using one-way ANOVA and Tukey’ s post-hoc test (p< 0. 05). Results: The pH-adjusted solutions exhibited better cell proliferation compared with the suspension groups. The combination of 0. 5mg/ml Ca(OH)2 solution and DFDBA increased the cell proliferation and mineralization compared with DFDBA per se (p= 0. 033). Conclusion: The combination of Ca(OH)2 with DFDBA improved the osteoinduc-tivity of DFDBA.

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    Cite

    APA: Copy

    KHOSROPANAH, HENGAMEH, LASHKARIZADEH, NAZILA, AYATOLLAHI, MARYAM, KAVIANI, MARYAM, & Mostafavipour, Zohreh. (2018). The Impact of Calcium Hydroxide on the Osteoinductive Capacity of Demineralized Freeze-Dried Bone Allograft: an In-Vitro Study. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), 19(1), 19-27. SID. https://sid.ir/paper/737456/en

    Vancouver: Copy

    KHOSROPANAH HENGAMEH, LASHKARIZADEH NAZILA, AYATOLLAHI MARYAM, KAVIANI MARYAM, Mostafavipour Zohreh. The Impact of Calcium Hydroxide on the Osteoinductive Capacity of Demineralized Freeze-Dried Bone Allograft: an In-Vitro Study. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2018;19(1):19-27. Available from: https://sid.ir/paper/737456/en

    IEEE: Copy

    HENGAMEH KHOSROPANAH, NAZILA LASHKARIZADEH, MARYAM AYATOLLAHI, MARYAM KAVIANI, and Zohreh Mostafavipour, “The Impact of Calcium Hydroxide on the Osteoinductive Capacity of Demineralized Freeze-Dried Bone Allograft: an In-Vitro Study,” JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), vol. 19, no. 1, pp. 19–27, 2018, [Online]. Available: https://sid.ir/paper/737456/en

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