THE ANALGESIC EFFECT OF ECHINOPHORA PLATYLOBA HYDROALCOHOLIC EXTRACT IN MALE RATS

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ASGARI NEMATIAN M.; MOHAMMADI S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS) Year:2016 | Volume:18 | Issue:5 Page(s): 31-37

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Title

THE ANALGESIC EFFECT OF ECHINOPHORA PLATYLOBA HYDROALCOHOLIC EXTRACT IN MALE RATS

Author(s)

ASGARI NEMATIAN M. | MOHAMMADI S. | Issue Writer Certificate

Keywords

HYDROALCOHOLIC EXTRACTQ2

ANALGESICQ3

ECHINOPHORA PLATYLOBAQ2

MEDICINAL HERBSQ2

Abstract

BACKGROUND AND OBJECTIVES: In traditional Iranian medicine, use of MEDICINAL HERBS is prevalent for the treatment and alleviation of pain and inflammation. ECHINOPHORA PLATYLOBA is one of the major MEDICINAL HERBS with confirmed anti-cancer, anti-microbial, and anti-fungal effects. Therefore, in this study, we aimed to evaluate the ANALGESIC effects of E. platyloba HYDROALCOHOLIC EXTRACTs in male rats.METHODS: In this experimental study, 42 rats were divided into six groups, i.e., control group, extract groups (80, 100, and 300 mg/kg via intraperitoneal injection), morphine group (1 mg/kg via intraperitoneal injection), and naloxone group (1 mg/kg of naloxone along with 300 mg/kg of the extract). To evaluate the ANALGESIC effects of the extracts, rating, tail flick, and formalin tests were performed.FINDINGS: In the writhing test, doses of 100 and 300 mg/kg of the extracts could decrease the rating score from 43.3±22.61 to 27.31±2.34 (p<0.05) and 29.0±67.91 (p<0.01) in the control group, respectively. In addition, administration of 300 mg/kg of the extract in tail flick test decreased the latency time from 2.84±0.76 to 5.52±1.88 sec in the control group (p<0.05). Moreover, in formalin test, 300 mg/kg of the extract reduced the pain score in both acute and chronic phases from 2.18±0.22 to 0.74±0.13 in the control group (p<0.01).CONCLUSION: According to the present results, E. platyloba HYDROALCOHOLIC EXTRACTs have central and peripheral ANALGESIC effects.

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APA: Copy

ASGARI NEMATIAN, M., & MOHAMMADI, S.. (2016). THE ANALGESIC EFFECT OF ECHINOPHORA PLATYLOBA HYDROALCOHOLIC EXTRACT IN MALE RATS. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 18(5), 31-37. SID. https://sid.ir/paper/73755/en

Vancouver: Copy

ASGARI NEMATIAN M., MOHAMMADI S.. THE ANALGESIC EFFECT OF ECHINOPHORA PLATYLOBA HYDROALCOHOLIC EXTRACT IN MALE RATS. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2016;18(5):31-37. Available from: https://sid.ir/paper/73755/en

IEEE: Copy

M. ASGARI NEMATIAN, and S. MOHAMMADI, “THE ANALGESIC EFFECT OF ECHINOPHORA PLATYLOBA HYDROALCOHOLIC EXTRACT IN MALE RATS,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 18, no. 5, pp. 31–37, 2016, [Online]. Available: https://sid.ir/paper/73755/en

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