مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Hydrogen-rich saline ameliorates hippocampal neuron apoptosis through up-regulating the expression of cystathionine β-synthase (CBS) after cerebral ischemia-reperfusion in rats

Pages

  494-499

Abstract

 Objective(s): This study aimed to evaluate the potential role of Hydrogen in Rats after cerebral ischemic/ reperfusion (I/R) injury. Materials and Methods: The experimental samples were composed of sham group, model group of Rats that received middle cerebral artery occlusion (MCAO) for 2 hr followed by reperfusion for 24 hr, and the Hydrogen saline group treated by hydro gen-rich saline (1 ml/kg) after MCAO. Hydrogen sulfide (H2S), S100-β protein (S100-β ), and neuron-specific enolase (NSE) levels were measured; the levels of malondialdehyde (MDA), reactive oxygen species (ROS), and superoxide dismutase (SOD) were detected; the histologic structure and apoptotic cells of Hippocampus were observed; the expressions of Cystathionine β-synthase (CBS), nuclear factor erythroid 2-related factor 2 (Nrf2), and hemeoxygenase-1 (HO-1) were measured. Statistical analyses were performed using one-way analysis of variance (ANOVA) followed by Fisher’ s least significant difference (LSD) test. Results: Our results showed that Hydrogen up-regulated H2S levels via promoting the expression of CBS in the Hippocampus, and its treatment alleviated oxidative stress via activating the expression of Nrf2 and HO-1, and then cell apoptosis reduced, furthermore, brain function improved by downregulating the levels of S100-β and NSE. Conclusion: This study showed that Hydrogen-rich saline ameliorates cell injury through upregulating the expression of CBS in the Hippocampus after cerebral ischemia reperfusion (I/R) in Rats, this provides new experimental evidence for the treatment of stroke with Hydrogen saline.

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    APA: Copy

    Cong, Hai ming, Gao, Qiu ping, Song, Guo qiang, Ye, Ying xin, Li, Xiao li, Zhang, Lian Shuang, & Wang, Xi Feng. (2020). Hydrogen-rich saline ameliorates hippocampal neuron apoptosis through up-regulating the expression of cystathionine β-synthase (CBS) after cerebral ischemia-reperfusion in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 23(4), 494-499. SID. https://sid.ir/paper/739060/en

    Vancouver: Copy

    Cong Hai ming, Gao Qiu ping, Song Guo qiang, Ye Ying xin, Li Xiao li, Zhang Lian Shuang, Wang Xi Feng. Hydrogen-rich saline ameliorates hippocampal neuron apoptosis through up-regulating the expression of cystathionine β-synthase (CBS) after cerebral ischemia-reperfusion in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2020;23(4):494-499. Available from: https://sid.ir/paper/739060/en

    IEEE: Copy

    Hai ming Cong, Qiu ping Gao, Guo qiang Song, Ying xin Ye, Xiao li Li, Lian Shuang Zhang, and Xi Feng Wang, “Hydrogen-rich saline ameliorates hippocampal neuron apoptosis through up-regulating the expression of cystathionine β-synthase (CBS) after cerebral ischemia-reperfusion in rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 23, no. 4, pp. 494–499, 2020, [Online]. Available: https://sid.ir/paper/739060/en

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