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Information Journal Paper

Title

The Eeffect of Metformin Combined with Calcium-Vitamin D3 Against Diet-Induced Nonalcoholic Fatty Liver Disease

Pages

  97-105

Abstract

 Purpose: Metformin is one of the most popular drugs tested against Nonalcoholic fatty liver disease (NAFLD). The present study aimed to investigate whether Calcium-Vitamin D3 cosupplementation will intensify the effect of Metformin on the prevention of high-fat, highfructose (HFFr) diet-induced hepatic steatosis. Methods: Male wistar rats (210± 16 g) were assigned into the following seven groups: a Control group to receive a standard chow and six HFFr-fed groups to receive diets containing either normal (0. 5% Calcium and 1000 IU/kg Vitamin D3) or high amount of Calcium and Vitamin D3 (2. 4% Calcium and 10000 IU/kg Vitamin D3) (CaD), in combination with gastric gavage administration of either saline or 25 or 200 mg/kg body weight/day Metformin. After 60 days, rats were assessed with respect to their anthropometric, metabolic and hepatic parameters, as well as their hepatic AMP-activated protein kinase (AMPK) phosphorylation. Results: Metformin and CaD, either alone or in combination, caused a significant reduction in HFFr diet-induced high serum aspartate aminotransferase (AST), hepatic steatosis and lipid accumulation without effect on insulin resistance and AMPK phosphorylation. In addition, slightly (and non-significantly) better effects of the combination in ameliorating steatosis and hepatic cholesterol content were observed. Conclusion: Taken together, our results suggest that Metformin and CaD could protect against the onset of HFFr diet-induced NAFLD in an insulin and AMPK-independent manner, without any marked additional benefits of their combination.

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    APA: Copy

    SHOJAEI ZARGHANI, SARA, Abbaszadeh, Samin, ALIZADEH, MOHAMMAD, RAMESHRAD, MARYAM, GARJANI, ALIREZA, & SORAYA, HAMID. (2018). The Eeffect of Metformin Combined with Calcium-Vitamin D3 Against Diet-Induced Nonalcoholic Fatty Liver Disease. ADVANCED PHARMACEUTICAL BULLETIN, 8(1), 97-105. SID. https://sid.ir/paper/739061/en

    Vancouver: Copy

    SHOJAEI ZARGHANI SARA, Abbaszadeh Samin, ALIZADEH MOHAMMAD, RAMESHRAD MARYAM, GARJANI ALIREZA, SORAYA HAMID. The Eeffect of Metformin Combined with Calcium-Vitamin D3 Against Diet-Induced Nonalcoholic Fatty Liver Disease. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2018;8(1):97-105. Available from: https://sid.ir/paper/739061/en

    IEEE: Copy

    SARA SHOJAEI ZARGHANI, Samin Abbaszadeh, MOHAMMAD ALIZADEH, MARYAM RAMESHRAD, ALIREZA GARJANI, and HAMID SORAYA, “The Eeffect of Metformin Combined with Calcium-Vitamin D3 Against Diet-Induced Nonalcoholic Fatty Liver Disease,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 8, no. 1, pp. 97–105, 2018, [Online]. Available: https://sid.ir/paper/739061/en

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