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Information Journal Paper

Title

In vitro cytotoxicity assay of D-limonene niosomes: an efficient nano-carrier for enhancing solubility of plant-extracted agents

Pages

  448-458

Abstract

 The low Solubility of the plant-extracted agent like D-limonene in Cancer therapy is a critical problem. In this study, we prepared D-limonene-loaded Niosomes (D-limonene/Nio) for Cancer therapy through in vitro cytotoxicity assay of HepG2, MCF-7, and A549 cell lines. The niosomal formulation was prepared by film hydration technique with Span® 40: Tween® 40: cholesterol (35: 35: 30 molar ratio) and characterized for vesicle distribution size, morphology, entrapment efficiency (EE%), and in vitro release behaviour. The obtained Niosomes showed a nanometric size and spherical morphology with EE% about 87 ± 1. 8%. Remarkably prolonged release of D-limonene from Niosomes compared to free D-limonene observed. The loaded formulation showed significantly enhanced cytotoxic activity with all three cancer cell lines (HepG2, Macf-7 and A549) at the concentration of 20 μ M. These results indicated that Niosome loaded with phytochemicals can be a promising nano-carrier for Cancer therapy applications.

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    APA: Copy

    HAJIZADEH, MOHAMMAD REZA, Maleki, Haniyeh, Barani, Mahmood, Fahmidehkar, Mohammad Ali, MAHMOODI, MEHDI, & TORKZADEH MAHANI, MASOUD. (2019). In vitro cytotoxicity assay of D-limonene niosomes: an efficient nano-carrier for enhancing solubility of plant-extracted agents. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), 14(5), 448-458. SID. https://sid.ir/paper/739065/en

    Vancouver: Copy

    HAJIZADEH MOHAMMAD REZA, Maleki Haniyeh, Barani Mahmood, Fahmidehkar Mohammad Ali, MAHMOODI MEHDI, TORKZADEH MAHANI MASOUD. In vitro cytotoxicity assay of D-limonene niosomes: an efficient nano-carrier for enhancing solubility of plant-extracted agents. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)[Internet]. 2019;14(5):448-458. Available from: https://sid.ir/paper/739065/en

    IEEE: Copy

    MOHAMMAD REZA HAJIZADEH, Haniyeh Maleki, Mahmood Barani, Mohammad Ali Fahmidehkar, MEHDI MAHMOODI, and MASOUD TORKZADEH MAHANI, “In vitro cytotoxicity assay of D-limonene niosomes: an efficient nano-carrier for enhancing solubility of plant-extracted agents,” RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), vol. 14, no. 5, pp. 448–458, 2019, [Online]. Available: https://sid.ir/paper/739065/en

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