EVALUATION OF P53 AND PCNA EXPRESSION IN ORAL LEUKOPLAKIC LESIONS WITH AND WITHOUT EPITHELIAL DYSPLASIA BY IMMUNOHISTOCHEMISTRY TECHNIQUE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOHTASHAM N.; SAGHARVANIAN N.A.; SHARIFI NOURIEH; SHAKERI M.T.; AMEL GHARIB SH.; SHOJAEI SETAREH

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Mashhad Dental School Year:2009 | Volume:33 | Issue:2 (69) Page(s): 169-176

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

718

Download:

Cites:

Information Journal Paper

Title

EVALUATION OF P53 AND PCNA EXPRESSION IN ORAL LEUKOPLAKIC LESIONS WITH AND WITHOUT EPITHELIAL DYSPLASIA BY IMMUNOHISTOCHEMISTRY TECHNIQUE

Author(s)

Keywords

ORAL LEUKOPLAKIAQ3

EPITHELIAL DYSPLASIAQ3

IMMUNOHISTOCHEMISTRYQ2

P53 AND PCNAQ3

Abstract

Introduction: Leukoplakia is the most common precancerous lesion of the oral mucosa and may range microscopically form benign hyperkeratosis to invasive squamous cell carcinoma. P53 is a tumor suppressor protein; whereas, proliferative cell nuclear antigen (PCNA) is a proliferative marker. The aim of this study was to evaluate the immunohistochemical expressions of P53 AND PCNA in ORAL LEUKOPLAKIA with and without dysplasia. Materials & Methods: The expression of P53 AND PCNA proteins were determined immunohistochemically in paraffin sections of 53 leukoplakias (17 without dyplasia, 15 with mild dysplasia, 14 with moderate dysplasia and 7 with severe dysplasia), in addition to 10 normal oral mucosa. Statistical analysis was performed using One-Way ANOVA, Kruskal-Wallis, and spearman tests. Results: P53 protein was expressed in 60% of normal oral mucosa, 82.4% of leukoplakias without dysplasia and 100% of leukoplakias with dysplasia. PCNA protein was expressed in all of the specimens. There were statistical differences between P53 AND PCNA expression among normal mucosa, leukoplakias with and without dysplasia, regarding their grading and severity (P<0.001). There was a positive correlation between P53 AND PCNA expression.Conclusion: Increase in P53 AND PCNA expression is related to the degree of dysplasia in ORAL LEUKOPLAKIAs. Therefore, we can use these markers in order to indicate and grade dysplastic lesions more exactly. PCNA and P53 could also be used as appropriate markers to estimate the potential of malignant transformation in ORAL LEUKOPLAKIA lesions.

Cites

No record.

References

No record.

Cite

APA: Copy

MOHTASHAM, N., SAGHARVANIAN, N.A., SHARIFI, NOURIEH, SHAKERI, M.T., AMEL GHARIB, SH., & SHOJAEI, SETAREH. (2009). EVALUATION OF P53 AND PCNA EXPRESSION IN ORAL LEUKOPLAKIC LESIONS WITH AND WITHOUT EPITHELIAL DYSPLASIA BY IMMUNOHISTOCHEMISTRY TECHNIQUE. JOURNAL OF MASHHAD DENTAL SCHOOL, 33(2 (69)), 169-176. SID. https://sid.ir/paper/73917/en

Vancouver: Copy

MOHTASHAM N., SAGHARVANIAN N.A., SHARIFI NOURIEH, SHAKERI M.T., AMEL GHARIB SH., SHOJAEI SETAREH. EVALUATION OF P53 AND PCNA EXPRESSION IN ORAL LEUKOPLAKIC LESIONS WITH AND WITHOUT EPITHELIAL DYSPLASIA BY IMMUNOHISTOCHEMISTRY TECHNIQUE. JOURNAL OF MASHHAD DENTAL SCHOOL[Internet]. 2009;33(2 (69)):169-176. Available from: https://sid.ir/paper/73917/en

IEEE: Copy

N. MOHTASHAM, N.A. SAGHARVANIAN, NOURIEH SHARIFI, M.T. SHAKERI, SH. AMEL GHARIB, and SETAREH SHOJAEI, “EVALUATION OF P53 AND PCNA EXPRESSION IN ORAL LEUKOPLAKIC LESIONS WITH AND WITHOUT EPITHELIAL DYSPLASIA BY IMMUNOHISTOCHEMISTRY TECHNIQUE,” JOURNAL OF MASHHAD DENTAL SCHOOL, vol. 33, no. 2 (69), pp. 169–176, 2009, [Online]. Available: https://sid.ir/paper/73917/en

Related Journal Papers