The Effects of Urtica dioica and Lamium album Extracts on the Expression Level of Cyclooxygenase-2 and Caspase-3 in the Liver and Kidney of Streptozotocin-Induced Diabetic Rats

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KHANAKI KOROSH; ABEDINZADE MAHMOOD; HAMIDI MASOUD

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Journal: PHARMACEUTICAL SCIENCES Year:2019 | Volume:25 | Issue:1 Page(s): 37-43

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Title

The Effects of Urtica dioica and Lamium album Extracts on the Expression Level of Cyclooxygenase-2 and Caspase-3 in the Liver and Kidney of Streptozotocin-Induced Diabetic Rats

Author(s)

KHANAKI KOROSH | ABEDINZADE MAHMOOD | HAMIDI MASOUD | Issue Writer Certificate

Keywords

Caspase-3 (CASP-3)

Cyclooxygenase-2 (COX-2)

Diabetes

Lamium album

Urtica dioica

Abstract

Background: Diabetes seems to be associated with increased inflammation and induced apoptosis in several tissues. Urtica dioica and Lamium album have shown to possess a variety of beneficial properties like anti-inflammatory effects. In this experimental study, we tried to evaluate the effects of U. dioica and L. album extracts on the expression level of cyclooxygenase-2 (COX-2; as an inflammation marker) and caspase-3 (CASP-3; as an apoptotic marker) in the liver and kidney tissues of diabetic rats. Methods: Thirty-two male Wistar rats were randomly allocated to four groups: normal control, diabetic control, diabetic treated with U. dioica (100 mg/kg/daily), and diabetic treated with L. album (100 mg/kg/daily) for 28 days. At the end of the study, liver and kidney tissues were harvested and mRNA expression level of COX-2 and CASP-3 was determined by real-time PCR technique. Also, serum glucose was measured. Results: Liver COX-2 mRNA in diabetic rats was significantly higher than normal control rats (P=0. 02). However, U. dioica and L. album caused significant decrease in mRNA expression of liver COX-2 in diabetic rats (P=0. 015 and P=0. 03, respectively). Also, in diabetic rats treated with both extracts, serum glucose was remarkably lower than diabetic control rats (P<0. 0001 and P<0. 01, respectively). Conclusion: It appears that U. dioica and L. album might decrease liver damage by decreasing the inflammatory effects of COX-2 in streptozocin-induced diabetic rats. Since these plant extracts may influence Diabetes by several mechanisms, further research in this field is warranted.

Cites

Effect of Eight Weeks of Aerobic Interval Training and Urtica dioica Supplement on Some Inflammatory Indicators and Glycemic Control in Men with Type 2 Diabetes

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APA: Copy

KHANAKI, KOROSH, ABEDINZADE, MAHMOOD, & HAMIDI, MASOUD. (2019). The Effects of Urtica dioica and Lamium album Extracts on the Expression Level of Cyclooxygenase-2 and Caspase-3 in the Liver and Kidney of Streptozotocin-Induced Diabetic Rats. PHARMACEUTICAL SCIENCES, 25(1), 37-43. SID. https://sid.ir/paper/739545/en

Vancouver: Copy

KHANAKI KOROSH, ABEDINZADE MAHMOOD, HAMIDI MASOUD. The Effects of Urtica dioica and Lamium album Extracts on the Expression Level of Cyclooxygenase-2 and Caspase-3 in the Liver and Kidney of Streptozotocin-Induced Diabetic Rats. PHARMACEUTICAL SCIENCES[Internet]. 2019;25(1):37-43. Available from: https://sid.ir/paper/739545/en

IEEE: Copy

KOROSH KHANAKI, MAHMOOD ABEDINZADE, and MASOUD HAMIDI, “The Effects of Urtica dioica and Lamium album Extracts on the Expression Level of Cyclooxygenase-2 and Caspase-3 in the Liver and Kidney of Streptozotocin-Induced Diabetic Rats,” PHARMACEUTICAL SCIENCES, vol. 25, no. 1, pp. 37–43, 2019, [Online]. Available: https://sid.ir/paper/739545/en

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