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Information Journal Paper

Title

Nigella sativa and its Derivatives as Food Toxicity Protectant Agents

Author(s)

 KARIMI ZAHRA | Alizadeh Adel Mirza | EZZATI NAZHAD DOLATABADI JAFAR | DEHGHAN PARVIN | Issue Writer Certificate 

Pages

  22-37

Abstract

 Exposure to food toxins generate multiple adverse health effects. Heavy metals, antibiotics residue, mycotoxins, pesticides and some food additives are examples of the most important food toxins. The common mechanism of toxicity and carcinogenicity effects of food toxins is the generation of Oxidative stress that leads to DNA damages. Moreover, based on epidemiologic evidence unhealthy eating habits and food toxicities are associated with cancers occurrence. Therefore, application of bioactive food additives as harmless or safe components in food industry is expensive. Nigella sativa L. is a broadly used herb-drug for various diseases all over the world and has been used as preservative and food additive. Based on various studies N. sativa has shown various pharmacological activities including therapeutic efficacy against different human diseases and antioxidant anti-inflammatory effects against environmental toxins. N. sativa decreases the adverse health effects induced by mentioned food toxins via modulating the action of antioxidant enzymes such as glutathione peroxidase (GPx), glutathione-S-transferase catalase and act as reactive oxygen species (ROS) scavengers in different organs. Besides, N. sativa and Thymoquinone (TQ) have protective effects on food products through removal and inhibition of various toxic compounds. Therefore, in the present review we will describe all protective effects of N. sativa and its main constituents, TQ, against food induced toxicities.

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    • Cite

    APA: Copy

    KARIMI, ZAHRA, Alizadeh, Adel Mirza, EZZATI NAZHAD DOLATABADI, JAFAR, & DEHGHAN, PARVIN. (2019). Nigella sativa and its Derivatives as Food Toxicity Protectant Agents. ADVANCED PHARMACEUTICAL BULLETIN, 9(1), 22-37. SID. https://sid.ir/paper/740107/en

    Vancouver: Copy

    KARIMI ZAHRA, Alizadeh Adel Mirza, EZZATI NAZHAD DOLATABADI JAFAR, DEHGHAN PARVIN. Nigella sativa and its Derivatives as Food Toxicity Protectant Agents. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2019;9(1):22-37. Available from: https://sid.ir/paper/740107/en

    IEEE: Copy

    ZAHRA KARIMI, Adel Mirza Alizadeh, JAFAR EZZATI NAZHAD DOLATABADI, and PARVIN DEHGHAN, “Nigella sativa and its Derivatives as Food Toxicity Protectant Agents,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 9, no. 1, pp. 22–37, 2019, [Online]. Available: https://sid.ir/paper/740107/en

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