مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

The Efficacy of Intravenous Versus Topical Use of Tranexamic Acid in Reducing Blood Loss after Primary Total Knee Arthroplasty: A Randomized Clinical Trial

Pages

  363-367

Abstract

 Background: Blood loss during and immediately after Total knee arthroplasty (TKA) is among the most challenging concerns. It has been demonstrated that Tranexamic acid (TXA) can help to reduce perioperative Blood loss. TXA can be used as an oral, Topical or Intravenous injection. Many studies evaluated the effectiveness of each route of administration but few works on a comparison between them. The current study aimed to compare the effectiveness of Intravenous injection versus Topical use of TXA in reducing perioperative Blood loss after primary Total knee arthroplasty. Methods: Eighty-five patients who were a candidate for Total knee arthroplasty were randomized into two groups: one group received Intravenous injection of 15 mg/kg TXA, 10 min before tourniquet inflation while the other group received 1 g diluted TXA during wound closure. The postoperative Blood loss was estimated by measuring the whole drain output and also hemoglobin (HB) drops. Both groups compared based on the need for allogenic blood transfusion and also thromboembolic events. Results: Patients who received Topical TXA had a higher total drain output (P<0. 0001) compared to Intravenous injection. The hemoglobin drop also was more in the Topical group although it was marginally significant (P=0. 05). Conclusion: Intravenous injection of TXA is more effective in reducing postoperative Blood loss after primary TKA compared to Topical administration.

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    Cite

    APA: Copy

    Torkaman, Ali, ROSTAMI, AMIR, Sarshar, Mohammad Reza, AKBARI AGHDAM, HOSSEIN, Motaghi, Paniz, & YAZDI, HAMID REZA. (2020). The Efficacy of Intravenous Versus Topical Use of Tranexamic Acid in Reducing Blood Loss after Primary Total Knee Arthroplasty: A Randomized Clinical Trial. THE ARCHIVES OF BONE AND JOINT SURGERY, 8(3), 363-367. SID. https://sid.ir/paper/740131/en

    Vancouver: Copy

    Torkaman Ali, ROSTAMI AMIR, Sarshar Mohammad Reza, AKBARI AGHDAM HOSSEIN, Motaghi Paniz, YAZDI HAMID REZA. The Efficacy of Intravenous Versus Topical Use of Tranexamic Acid in Reducing Blood Loss after Primary Total Knee Arthroplasty: A Randomized Clinical Trial. THE ARCHIVES OF BONE AND JOINT SURGERY[Internet]. 2020;8(3):363-367. Available from: https://sid.ir/paper/740131/en

    IEEE: Copy

    Ali Torkaman, AMIR ROSTAMI, Mohammad Reza Sarshar, HOSSEIN AKBARI AGHDAM, Paniz Motaghi, and HAMID REZA YAZDI, “The Efficacy of Intravenous Versus Topical Use of Tranexamic Acid in Reducing Blood Loss after Primary Total Knee Arthroplasty: A Randomized Clinical Trial,” THE ARCHIVES OF BONE AND JOINT SURGERY, vol. 8, no. 3, pp. 363–367, 2020, [Online]. Available: https://sid.ir/paper/740131/en

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