Stomach-Specific Drug Delivery of Clarithromycin Using a Semi Interpenetrating Polymeric Network Hydrogel Made of Montmorillonite and Chitosan: Synthesis, Characterization and In Vitro Drug Release Study

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

PANAHI YUNES; GHAREKHANI AFSHIN; HAMISHEHKAR HAMED; ZAKERI MILANI PARVIN; Gharekhani Hamed

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Advanced Pharmaceutical Bulletin Year:2019 | Volume:9 | Issue:1 Page(s): 159-173

Download Full-Text

View:

122

Download:

112

Cites:

Information Journal Paper

Title

Stomach-Specific Drug Delivery of Clarithromycin Using a Semi Interpenetrating Polymeric Network Hydrogel Made of Montmorillonite and Chitosan: Synthesis, Characterization and In Vitro Drug Release Study

Author(s)

Keywords

Semi-interpenetrating polymer network

Chitosan

Montmorillonite

Clarithromycin

Gastroretentive drug delivery formulation

Abstract

Purpose: In this study, we aimed to prepare an extended drug delivery formulation of Clarithromycin (CAM) based on a Semi-interpenetrating polymer network (semi-IPN) hydrogel. Methods: Synthesis of semi-IPN hydrogel nanocomposite made of Chitosan (CS), acrylic acid (AA), acrylamide (AAm), polyvinylpyrrolidone (PVP), and Montmorillonite (MMT) was performed by free radical graft copolymerization method. Swelling kinetic studies were done in acidic buffer solutions of hydrochloric acid (pH = 1. 2), acetate (pH = 4), and also distilled water. Also, the effects of MMT on the swelling kinetic, thermal stability, and mechanical strength of the hydrogels were evaluated. Moreover, in vitro release behavior of CAM and its release kinetics from hydrogels were studied in a hydrochloric acid buffer solution. Results: Fourier transform infrared spectroscopy (FTIR) results revealed that synthesis of semi-IPN superabsorbent nanocomposite and CAM incorporation into hydrogel was performed, successfully. Introducing MMT into hydrogel network not only improved its thermal stability but also increased mechanical strength of the final hydrogel product. Also, in comparison with neat hydrogel (1270 g/g), hydrogel nanocomposite containing 13 wt% MMT exhibited greater equilibrium swelling capacity (1568 g/g) with lower swelling rate. In vitro drug release experiments showed that CS-g-poly(AA-co-AAm)/PVP/MMT/CAM formulation possesses a sustained release character over extended period of time compared with CS-g-poly(AA-co-AAm)/PVP/CAM formulation. Conclusion: In the presence of MMT, the effective life time of drug is prolonged, demonstrating a sustained release property. The reason is that interlinked porous channels within superabsorbent nanocomposite network hinder penetration of aqueous solutions into hydrogel and subsequently cause a slower drug release.

Cites

No record.

References

No record.

Cite

APA: Copy

PANAHI, YUNES, GHAREKHANI, AFSHIN, HAMISHEHKAR, HAMED, ZAKERI MILANI, PARVIN, & Gharekhani, Hamed. (2019). Stomach-Specific Drug Delivery of Clarithromycin Using a Semi Interpenetrating Polymeric Network Hydrogel Made of Montmorillonite and Chitosan: Synthesis, Characterization and In Vitro Drug Release Study. ADVANCED PHARMACEUTICAL BULLETIN, 9(1), 159-173. SID. https://sid.ir/paper/740240/en

Vancouver: Copy

PANAHI YUNES, GHAREKHANI AFSHIN, HAMISHEHKAR HAMED, ZAKERI MILANI PARVIN, Gharekhani Hamed. Stomach-Specific Drug Delivery of Clarithromycin Using a Semi Interpenetrating Polymeric Network Hydrogel Made of Montmorillonite and Chitosan: Synthesis, Characterization and In Vitro Drug Release Study. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2019;9(1):159-173. Available from: https://sid.ir/paper/740240/en

IEEE: Copy

YUNES PANAHI, AFSHIN GHAREKHANI, HAMED HAMISHEHKAR, PARVIN ZAKERI MILANI, and Hamed Gharekhani, “Stomach-Specific Drug Delivery of Clarithromycin Using a Semi Interpenetrating Polymeric Network Hydrogel Made of Montmorillonite and Chitosan: Synthesis, Characterization and In Vitro Drug Release Study,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 9, no. 1, pp. 159–173, 2019, [Online]. Available: https://sid.ir/paper/740240/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops