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Information Journal Paper

Title

Omitting ALND Is Not Safe for a Cohort of Early-Stage Breast Cancer Patients with 1-2 SLNs Macro-Metastases and BreastConserving Therapy: A Single-Center Retrospective Study

Pages

  1262-1268

Abstract

 Background: Omitting axillary lymph node dissection (ALND) is recommended for early-stage Breast cancer patients with 1-2 sentinel lymph nodes (SLNs) Macro-metastases and breast-conserving therapy. However, it is not safe for part of patients, so it is significant to find risk factors and develop a Predictive model of non-SLNs metastases in Breast cancer patients with 1-2 SLNs Macro-metastases and breast-conserving therapy. Methods: This retrospective study enrolled 228 Breast cancer patients with 1-2 SLNs Macro-metastases who underwent ALND and Breast-conserving surgery between Jan 2012 and Dec 2017 at Cancer Hospital Chinese Academy of Medical Sciences. Chi-square test and backward stepwise binary logistic regression were used to find factors that influenced non-SLN metastases, then a Predictive model was formulated and obtained its area under the curve. Results: Tumor pathologic invasion size, number of positive SLNs and ALN status on imaging was associated with non-SLNs metastases. The Predictive model was also formulated based on these three factors to assess and the area under the curve of model was 0. 708. Conclusion: We developed a Predictive model to assess the high-risk cohort of patients of non-SLNs metastases which can be an auxiliary tool for doctors.

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    APA: Copy

    WANG, Xiangyu, GAO, Yinqi, YANG, XUE, KONG, Xiangyi, WANG, Zixing, FANG, Yi, & WANG, JING. (2020). Omitting ALND Is Not Safe for a Cohort of Early-Stage Breast Cancer Patients with 1-2 SLNs Macro-Metastases and BreastConserving Therapy: A Single-Center Retrospective Study. IRANIAN JOURNAL OF PUBLIC HEALTH, 49(7), 1262-1268. SID. https://sid.ir/paper/740327/en

    Vancouver: Copy

    WANG Xiangyu, GAO Yinqi, YANG XUE, KONG Xiangyi, WANG Zixing, FANG Yi, WANG JING. Omitting ALND Is Not Safe for a Cohort of Early-Stage Breast Cancer Patients with 1-2 SLNs Macro-Metastases and BreastConserving Therapy: A Single-Center Retrospective Study. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2020;49(7):1262-1268. Available from: https://sid.ir/paper/740327/en

    IEEE: Copy

    Xiangyu WANG, Yinqi GAO, XUE YANG, Xiangyi KONG, Zixing WANG, Yi FANG, and JING WANG, “Omitting ALND Is Not Safe for a Cohort of Early-Stage Breast Cancer Patients with 1-2 SLNs Macro-Metastases and BreastConserving Therapy: A Single-Center Retrospective Study,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 49, no. 7, pp. 1262–1268, 2020, [Online]. Available: https://sid.ir/paper/740327/en

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