Preparation and Characterization of Celecoxib Agglomerated Nanocrystals and Dry Powder Inhalation Formulations to Improve its Aerosolization Performance

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Mardani Sepideh; MAGHSOODI MARYAM; GHANBARZADEH SAEED; NOKHODCHI ALI; Yaqoubi Shadi; HAMISHEHKAR HAMED

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: PHARMACEUTICAL SCIENCES Year:2017 | Volume:23 | Issue:4 Page(s): 278-284

Download Full-Text

View:

116

Download:

Cites:

Information Journal Paper

Title

Preparation and Characterization of Celecoxib Agglomerated Nanocrystals and Dry Powder Inhalation Formulations to Improve its Aerosolization Performance

Author(s)

Keywords

Celecoxib

Dry powder inhaler

Nanocrystals

Agglomeration

Pulmonary drug delivery

Abstract

Background: Celecoxib is a non-steroidal anti-inflammatory drug used extensively in the treatment of pain, arthritis, and cancers. However, its administration is limited due to its several disadvantages including gastric irritation and hepatic first pass metabolism. Among numerous methods for Pulmonary drug delivery, dry powder inhalation systems show the promising approach to be used as alternative routes for oral drug delivery. This study was conducted to develop agglomerated Nanocrystals and carrier-free Celecoxib dry powder inhalation formulation for pulmonary delivery in lung cancer treatment. Methods: Spray dried Celecoxib, Celecoxib Nanocrystals, and agglomerated Nanocrystals were characterized in the case of particle size distribution, crystallinity, and aerosolization efficiency including mass median aerodynamic diameter (MMAD), fine particle fraction (FPF), and geometric standard deviation (GSD) by Next Generation Impactor (NGI). Results: Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) analyses showed the lack of any interaction and polymorphism in the prepared formulations. Results showed that the optimized spray-dried formulation of Celecoxib was in the appropriate size range, and shape for pulmonary delivery. MMAD, FPF, and GSD values for spray-dried formulation were 31. 93± 3. 93%, 4. 82± 0. 21 μ m, and 1. 81± 0. 05, respectively. Conclusion: Although the agglomerated Nanocrystals of Celecoxib showed comparable aerosolization efficiency indexes with carrier free spray-dried Celecoxib formulation, further investigations are necessary to optimize the Agglomeration process to obtain agglomerated Nanocrystals of Celecoxib with improved aerosolization efficiency indexes.

Cites

No record.

References

No record.

Cite

APA: Copy

Mardani, Sepideh, MAGHSOODI, MARYAM, GHANBARZADEH, SAEED, NOKHODCHI, ALI, Yaqoubi, Shadi, & HAMISHEHKAR, HAMED. (2017). Preparation and Characterization of Celecoxib Agglomerated Nanocrystals and Dry Powder Inhalation Formulations to Improve its Aerosolization Performance. PHARMACEUTICAL SCIENCES, 23(4), 278-284. SID. https://sid.ir/paper/740470/en

Vancouver: Copy

Mardani Sepideh, MAGHSOODI MARYAM, GHANBARZADEH SAEED, NOKHODCHI ALI, Yaqoubi Shadi, HAMISHEHKAR HAMED. Preparation and Characterization of Celecoxib Agglomerated Nanocrystals and Dry Powder Inhalation Formulations to Improve its Aerosolization Performance. PHARMACEUTICAL SCIENCES[Internet]. 2017;23(4):278-284. Available from: https://sid.ir/paper/740470/en

IEEE: Copy

Sepideh Mardani, MARYAM MAGHSOODI, SAEED GHANBARZADEH, ALI NOKHODCHI, Shadi Yaqoubi, and HAMED HAMISHEHKAR, “Preparation and Characterization of Celecoxib Agglomerated Nanocrystals and Dry Powder Inhalation Formulations to Improve its Aerosolization Performance,” PHARMACEUTICAL SCIENCES, vol. 23, no. 4, pp. 278–284, 2017, [Online]. Available: https://sid.ir/paper/740470/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops