Transient modulation of hydroxyzine, an antihistamine and anxiolytic agent, on the cardiac autonomic activity in healthy subjects

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Rezaeyanzade Fateme; AHANGAR NEMATOLLAH; ALIPOUR ABBAS; GHAEMIAN ALI; AKBARI ESMAEIL

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Physiology and Pharmacology Year:2019 | Volume:23 | Issue:1 Page(s): 59-69

Download Full-Text

View:

172

Download:

Cites:

Information Journal Paper

Title

Transient modulation of hydroxyzine, an antihistamine and anxiolytic agent, on the cardiac autonomic activity in healthy subjects

Author(s)

Keywords

Histamine

Heart rate variability

Hydroxyzine

Autonomic nervous system

Abstract

Introduction: Despite the experimental evidence available on the modulating effects of the H1 receptors on the autonomic function, limited research has been done the effects of such receptors through measuring the Heart rate variability (HRV) indexes in human. The present study aims to assess the effect of the acute administration of different doses of Hydroxyzine on the time and frequency domain of HRV indexes. Methods: Four experiment sessions were held for the fifteen healthy participants. In each session, after the 5-minute baseline electrocardiogram (ECG) recording, one of the four interventions (the intake of a 5, 10 or 20mg Hydroxyzine or a placebo) was performed and then the 5-minute ECG recordings were repeated at 30, 60, 90, 120, 180 and 240 minutes after the oral administration. Results: The statistical analysis has shown that at minute 30, Hydroxyzine has an inhibitory effect on the sympathetic index low frequency (LFnu), which is eliminated at minute 180. Moreover, from minute 60, Hydroxyzine increases vagal HRV indexes, which are then eliminated at minute 240. Conclusion: The findings of the present study showed that Histamines, mediated by H1 receptors, have a modulating effect on the cardiac autonomic; however, this modulating effect is then neutralized or eliminated in a short time probably by other cardiac regulatory mechanisms.

Cites

No record.

References

Normative values of short-term heart rate variability parameters in Koreans and their clinical value for the prediction of mortality

Cite

APA: Copy

Rezaeyanzade, Fateme, AHANGAR, NEMATOLLAH, ALIPOUR, ABBAS, GHAEMIAN, ALI, & AKBARI, ESMAEIL. (2019). Transient modulation of hydroxyzine, an antihistamine and anxiolytic agent, on the cardiac autonomic activity in healthy subjects. PHYSIOLOGY AND PHARMACOLOGY, 23(1), 59-69. SID. https://sid.ir/paper/740990/en

Vancouver: Copy

Rezaeyanzade Fateme, AHANGAR NEMATOLLAH, ALIPOUR ABBAS, GHAEMIAN ALI, AKBARI ESMAEIL. Transient modulation of hydroxyzine, an antihistamine and anxiolytic agent, on the cardiac autonomic activity in healthy subjects. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2019;23(1):59-69. Available from: https://sid.ir/paper/740990/en

IEEE: Copy

Fateme Rezaeyanzade, NEMATOLLAH AHANGAR, ABBAS ALIPOUR, ALI GHAEMIAN, and ESMAEIL AKBARI, “Transient modulation of hydroxyzine, an antihistamine and anxiolytic agent, on the cardiac autonomic activity in healthy subjects,” PHYSIOLOGY AND PHARMACOLOGY, vol. 23, no. 1, pp. 59–69, 2019, [Online]. Available: https://sid.ir/paper/740990/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops