Pelargonidin improves amyloid β-induced deficits in the long-term potentiation in hippocampus of male rats

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SOLEIMANI ASL SARA; LOS MAREK J.; MEHDIZADEH MEHDI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Physiology and Pharmacology Year:2019 | Volume:23 | Issue:4 Page(s): 296-301

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Information Journal Paper

Title

Pelargonidin improves amyloid β-induced deficits in the long-term potentiation in hippocampus of male rats

Author(s)

SOLEIMANI ASL SARA | LOS MAREK J. | MEHDIZADEH MEHDI | Issue Writer Certificate

Keywords

Amyloid β

-peptide

Pelargonidin

Long-term potentiation

Hippocampus

Abstract

Introduction: Given that Pelargonidin is an anthocyanin that exhibits neuroprotective effects and Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the accumulation of amyloid-beta (Aβ ) and cognitive dysfunction subsequently, herein, we examined the effects of Pelargonidin on Aβ-induced longterm potentiation deficits in rats. Methods: AD was induced using intrahippocampal injections of the Aβ in the adult Wistar male rats. The rats received single intraperitoneal injections of Pelargonidin (3mg/kg). Long-term potentiation in the perforant path-dentate gyrus synapses was assessed electrophysiologically by measuring the field excitatory post-synaptic potential (fEPSP) slope and population spike (PS) amplitude. Results: Our results showed that Aβ significantly decreased fEPSP slope and SP amplitude in comparison with the control and sham groups, whereas Pelargonidin increased these parameters in comparison to the Aβ group. Conclusion: It is probably that Pelargonidin could improve Aβ-induced cognition deficit in rats.

Cites

Protective effect of chronic administration of pelargonidin on neuronal apoptosis and memory process in amyloid-beta-treated rats

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APA: Copy

SOLEIMANI ASL, SARA, LOS, MAREK J., & MEHDIZADEH, MEHDI. (2019). Pelargonidin improves amyloid β-induced deficits in the long-term potentiation in hippocampus of male rats. PHYSIOLOGY AND PHARMACOLOGY, 23(4), 296-301. SID. https://sid.ir/paper/741004/en

Vancouver: Copy

SOLEIMANI ASL SARA, LOS MAREK J., MEHDIZADEH MEHDI. Pelargonidin improves amyloid β-induced deficits in the long-term potentiation in hippocampus of male rats. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2019;23(4):296-301. Available from: https://sid.ir/paper/741004/en

IEEE: Copy

SARA SOLEIMANI ASL, MAREK J. LOS, and MEHDI MEHDIZADEH, “Pelargonidin improves amyloid β-induced deficits in the long-term potentiation in hippocampus of male rats,” PHYSIOLOGY AND PHARMACOLOGY, vol. 23, no. 4, pp. 296–301, 2019, [Online]. Available: https://sid.ir/paper/741004/en

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