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Information Journal Paper

Title

The Role of Gene Therapy in Cartilage Repair (CURRENT CONCEPTS REVIEW)

Pages

  79-90

Abstract

 The key principle of gene delivery to articulations by direct intra-articular injection is to release complementary DNA (cDNA)-encoding medical products that will lead to maintained, endogenous production of the gene products within the articulation. In fact, this has been accomplished for both in vivo and ex vivo gene delivery, using several vectors, genes, and cells in some animal models. Some clinical trials for rheumatoid arthritis and osteoarthritis (OA) using retrovirus vectors for ex vivo gene delivery and adeno-associated virus (AAV) for in vivo delivery have been reported. AAV is of special attention because, contrary to other viral vectors, it can enter deep within joint Cartilage and transduce chondrocytes in situ. This quality is of special significance in OA, in which modifications in chondrocyte metabolism are believed to be crucial to the pathophysiology of the disease. The clinical effectiveness of TissueGene-C (TG-C), a cell and Gene therapy for OA consisting of nontransformed and transduced chondrocytes (3: 1) retrovirally transduced to overexpress TGF-β 1 has been reported in patients with knee OA. The most common complications of TG-C were peripheral edema (9%), arthralgia (8%), articular swelling (6%), and injection site pain (5%). TG-C was associated with relevant ameliorations in function and pain. Gene therapy appears to be a viable method for the management of articular Cartilage defects and OA.

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    Cite

    APA: Copy

    Rodriguez Merchan, E.Carlos, & Valentino, Leonard A.. (2019). The Role of Gene Therapy in Cartilage Repair (CURRENT CONCEPTS REVIEW). THE ARCHIVES OF BONE AND JOINT SURGERY, 7(2), 79-90. SID. https://sid.ir/paper/742126/en

    Vancouver: Copy

    Rodriguez Merchan E.Carlos, Valentino Leonard A.. The Role of Gene Therapy in Cartilage Repair (CURRENT CONCEPTS REVIEW). THE ARCHIVES OF BONE AND JOINT SURGERY[Internet]. 2019;7(2):79-90. Available from: https://sid.ir/paper/742126/en

    IEEE: Copy

    E.Carlos Rodriguez Merchan, and Leonard A. Valentino, “The Role of Gene Therapy in Cartilage Repair (CURRENT CONCEPTS REVIEW),” THE ARCHIVES OF BONE AND JOINT SURGERY, vol. 7, no. 2, pp. 79–90, 2019, [Online]. Available: https://sid.ir/paper/742126/en

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