The Effect of Gentamycin in the Irrigating Solution to Prevent Joint Infection after Anterior Cruciate Ligament (ACL) Reconstruction

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YAZDI HAMID REZA; YOUSOF GOMROKCHI ALIREZA; Nazarian Ara; Lechtig Aron; Hanna Philip; GHORBAN HOSEINI MOHAMMAD

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Journal: Archives of Bone and Joint Surgery Year:2019 | Volume:7 | Issue:1 Page(s): 67-74

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Title

The Effect of Gentamycin in the Irrigating Solution to Prevent Joint Infection after Anterior Cruciate Ligament (ACL) Reconstruction

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Keywords

ACL reconstruction

Gentamicin

Irrigating solution

Septic arthritis

Abstract

Background: Arthroscopic reconstruction of ACL is an effective method to restore knee stability after ACL rupture. Postoperative Septic arthritis (SA) is very uncommon while the incidence of serious complications range between 0. 14% and 1. 8%. Some of the devastating consequences of Septic arthritis can encompass hyaline cartilage damage, arthrofibrosis, and in rare cases amputation. The purpose of this study was to evaluate the effect of Gentamicin irrigation solutions as a process to restrain Septic arthritis following arthroscopic ACL reconstruction. Methods: In this retrospective cohort study, 1464 patients who underwent ACL reconstruction with hamstring tendon autograft in our institution over 7 years (February 2008 to January 2015) were included. The patients were divided into two groups based on the type of intra-articular irrigation solution used during the surgery. Patients in Group 1 (Saline) received intra-articular irrigation with normal saline (0. 9 % sodium chloride) solution, while those in Group 2 (Gentamycin) received intra-articular irrigation with Gentamicin (80 mg/L) added to the normal saline solution. Data about postoperative infection, its course, management, and outcome were obtained from patients’ records. Results: Seven patients developed SA, four of whom were from SALINE group (2. 2%) and three from Gentamycin group (0. 23%). The incidence rate of SA after arthroscopic ACL reconstruction was significantly lower (P <0. 05) when irrigated with Gentamicin solution than merely with saline solution. Conclusion: Gentamicin irrigation solution has a preservative and protective effect against SA development following arthroscopic ACL reconstruction. We recommend evaluating this technique as a way in order to depreciate the prevalence of SA after ACL reconstruction.

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APA: Copy

YAZDI, HAMID REZA, YOUSOF GOMROKCHI, ALIREZA, Nazarian, Ara, Lechtig, Aron, Hanna, Philip, & GHORBAN HOSEINI, MOHAMMAD. (2019). The Effect of Gentamycin in the Irrigating Solution to Prevent Joint Infection after Anterior Cruciate Ligament (ACL) Reconstruction. THE ARCHIVES OF BONE AND JOINT SURGERY, 7(1), 67-74. SID. https://sid.ir/paper/742138/en

Vancouver: Copy

YAZDI HAMID REZA, YOUSOF GOMROKCHI ALIREZA, Nazarian Ara, Lechtig Aron, Hanna Philip, GHORBAN HOSEINI MOHAMMAD. The Effect of Gentamycin in the Irrigating Solution to Prevent Joint Infection after Anterior Cruciate Ligament (ACL) Reconstruction. THE ARCHIVES OF BONE AND JOINT SURGERY[Internet]. 2019;7(1):67-74. Available from: https://sid.ir/paper/742138/en

IEEE: Copy

HAMID REZA YAZDI, ALIREZA YOUSOF GOMROKCHI, Ara Nazarian, Aron Lechtig, Philip Hanna, and MOHAMMAD GHORBAN HOSEINI, “The Effect of Gentamycin in the Irrigating Solution to Prevent Joint Infection after Anterior Cruciate Ligament (ACL) Reconstruction,” THE ARCHIVES OF BONE AND JOINT SURGERY, vol. 7, no. 1, pp. 67–74, 2019, [Online]. Available: https://sid.ir/paper/742138/en

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