Protective effects of Sanguisorba minor and Ferulago angulata total extracts against beta-amyloid induced cytotoxicity and oxidative stress in cultured cerebellar granule neurons

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Akbari Sholeh; SOODI MALIHEH; HAJIMEHDIPOOR HOMA; ATAEI NASIM

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Journal Paper

Paper Information

Journal: JOURNAL OF HERBMED PHARMACOLOGY Year:2019 | Volume:8 | Issue:3 Page(s): 248-255

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Title

Protective effects of Sanguisorba minor and Ferulago angulata total extracts against beta-amyloid induced cytotoxicity and oxidative stress in cultured cerebellar granule neurons

Author(s)

Akbari Sholeh | SOODI MALIHEH | HAJIMEHDIPOOR HOMA | ATAEI NASIM | Issue Writer Certificate

Keywords

Sanguisorba minor

Ferulago angulata

Alzheimer’s disease

Oxidative stress

Neuroprotection

Abstract

Introduction: Alzheimer’ s disease (AD) is an age-dependent neurodegenerative disorder and major cause of mortality in the elderly. AD has a complex pathophysiology and needs new multi-targeted compounds to halt the disease progression through several mechanisms. Medicinal plants contain various compounds with heterogeneous pharmacological effects, therefore are a good source. The aim of this study was to evaluate the protective effect of total extracts of Sanguisorba minor and Ferulago angulata on beta-amyloid (Aβ )-induced toxicity in primary neural cell culture. Methods: Cerebellar granule neurons (CGNs) were cultured according to standard protocols. The cultured neurons were incubated with Aβ alone or in combination with different concentrations of extracts for 24 hours. Cell viability was measured by methylthiazolyldiphenyl-tetrazolium (MTT) assay. In addition acetylcholinesterase (AChE) activity and Oxidative stress markers were measured after incubation. Also, the effects of different concentrations of the extracts on AChE activity of the cultured neurons were investigated. For measuring the acute toxicity of the extract, LD50 was estimated by limit test. Results: Both extracts could protect CGNs against Aβ-induced cell death. Aβ-induced Oxidative stress and increase of AChE activity were ameliorated by both extracts. S. minor extract dose-dependently reduced AChE activity in cultured CGNs. LD50 of both extracts was estimated above 2000 mg/kg and considered as safe. Conclusion: Both studied extracts protected CGNs against Aβ-induced toxicity by ameliorating Oxidative stress mechanism. According to these results, these extracts are recommended for further investigation in AD treatment.

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APA: Copy

Akbari, Sholeh, SOODI, MALIHEH, HAJIMEHDIPOOR, HOMA, & ATAEI, NASIM. (2019). Protective effects of Sanguisorba minor and Ferulago angulata total extracts against beta-amyloid induced cytotoxicity and oxidative stress in cultured cerebellar granule neurons. JOURNAL OF HERBMED PHARMACOLOGY, 8(3), 248-255. SID. https://sid.ir/paper/742188/en

Vancouver: Copy

Akbari Sholeh, SOODI MALIHEH, HAJIMEHDIPOOR HOMA, ATAEI NASIM. Protective effects of Sanguisorba minor and Ferulago angulata total extracts against beta-amyloid induced cytotoxicity and oxidative stress in cultured cerebellar granule neurons. JOURNAL OF HERBMED PHARMACOLOGY[Internet]. 2019;8(3):248-255. Available from: https://sid.ir/paper/742188/en

IEEE: Copy

Sholeh Akbari, MALIHEH SOODI, HOMA HAJIMEHDIPOOR, and NASIM ATAEI, “Protective effects of Sanguisorba minor and Ferulago angulata total extracts against beta-amyloid induced cytotoxicity and oxidative stress in cultured cerebellar granule neurons,” JOURNAL OF HERBMED PHARMACOLOGY, vol. 8, no. 3, pp. 248–255, 2019, [Online]. Available: https://sid.ir/paper/742188/en

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