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Title

Outcomes of Preimplantation Genetic Testing for Single Gene Defects in a Privately Funded Period and Publicly Funded Period: A North-American Single Center Experience

Pages

  107-115

Abstract

 Background: The purpose of this study was to assess whether the outcomes from IVF-Preimplantation genetic testing (IVF-PGT) cycles for Single gene defects (SGD) (PGT-M) differ between a privately funded period (PRP) and publicly funded period (PUP). Methods: A retrospective cohort study was conducted in a North-American single tertiary center. The PRP (March 1998 to July 2010) comprised 56 PGT-M cycles from 58 IVF cycles in 38 couples, and the PUP (August 2010 to May 2015) comprised 59 PGT-M cycles from 87 IVF cycles in 38 couples. One PGT-M cycle is defined as one biopsy procedure from one or serial IVF cycles. A p-value of 0. 05 was considered statistically significant. Results: The clinical pregnancy rates (CPR) per PGT-M cycle were 30. 4% and 52. 5% in each period, respectively (p=0. 021). The live birth rates (LBR) per PGT-M cycle were 21. 5% versus 40. 9% in each period, respectively (p=0. 037). A sub-analysis within the PUP comparing 39 PGT-M cycles from 39 IVF cycles with 20 PGTM cycles from 49 IVF cycles yielded CPRs per PGT-M cycle of 64. 1% and 30. 0% and LBRs per PGT-M cycle of 53. 8% and 15. 0%, in each group, respectively (p< 0. 05 for both). Conclusion: The transition from private to Public funding and a Single embryo transfer (ET) guideline has little impact on embryological and clinical outcomes of PGT-M cycles, and results in lower rates of multiple pregnancies. However, these two systems may serve different populations.

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    APA: Copy

    Shaulov, Talya, ZHANG, LI, Chung, Jin Tae, Son, Weon Young, & Buckett, William. (2020). Outcomes of Preimplantation Genetic Testing for Single Gene Defects in a Privately Funded Period and Publicly Funded Period: A North-American Single Center Experience. JOURNAL OF REPRODUCTION AND INFERTILITY, 21(2), 107-115. SID. https://sid.ir/paper/742334/en

    Vancouver: Copy

    Shaulov Talya, ZHANG LI, Chung Jin Tae, Son Weon Young, Buckett William. Outcomes of Preimplantation Genetic Testing for Single Gene Defects in a Privately Funded Period and Publicly Funded Period: A North-American Single Center Experience. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2020;21(2):107-115. Available from: https://sid.ir/paper/742334/en

    IEEE: Copy

    Talya Shaulov, LI ZHANG, Jin Tae Chung, Weon Young Son, and William Buckett, “Outcomes of Preimplantation Genetic Testing for Single Gene Defects in a Privately Funded Period and Publicly Funded Period: A North-American Single Center Experience,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 21, no. 2, pp. 107–115, 2020, [Online]. Available: https://sid.ir/paper/742334/en

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