EVALUATION OF THE EFFECTS OF CHRONIC PERIODONTITIS ON TLR-2 AND TLR-4 GENE EXPRESSION IN GINGIVAL TISSUES

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FATEMI KAZEM; RADVAR MEHRDAD; REZAEE ABDOLRAHIM; ARAB HAMIDREZA; RAFAATPANAH HOOSHANG; AZANGOOKHIAVI HASSAN; DADPOUR YALDA

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Journal: Journal of Mashhad Dental School Year:2012 | Volume:35 | Issue:4 (79) Page(s): 297-306

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Title

EVALUATION OF THE EFFECTS OF CHRONIC PERIODONTITIS ON TLR-2 AND TLR-4 GENE EXPRESSION IN GINGIVAL TISSUES

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Keywords

CHRONIC PERIODONTITISQ2

TLR-2Q2

TLR-4Q2

REAL-TIME PCRQ2

Abstract

Introduction: In periodontal diseases, pathogen discrimination by the immune system is an essential factor for triggering host responses. The Toll-like receptor family is responsible for recognition of evolutionarily conserved microbial structures like bacterial lipopolysaccharide (LPS) and activates signaling pathways that eventually lead to immune responses. The aim of the present study was to use REAL-TIME PCR to compare TLR-2 and TLR-4 gene expression levels in diseased sites and healthy sites of gingival tissue from periodontitis patients.Materials & Methods: Gingival biopsies were harvested from healthy sites (BOP- and PD£3mm) and diseased sites (BOP+ and PD³5mm) of 20 patients with moderate to severe CHRONIC PERIODONTITIS. RNA was extracted from all gingival biopsies. REAL-TIME PCR was performed to evaluate relative quantities of TLR-2 and TLR-4 mRNA. Statistical analyses were done using the Paired Wilcoxon test (2 related sample tests).Results: The relative expression levels of both TLR-2 and TLR-4 were significantly higher at diseased sites (2.41±2.06 and 1.25±1.16) than at healthy sites (0.91±1.04 and 0.41±0.60) (P£0.01).Conclusion: Periodontal disease can significantly increase TLR-2 and TLR-4 gene expression in gingival tissues.

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APA: Copy

FATEMI, KAZEM, RADVAR, MEHRDAD, REZAEE, ABDOLRAHIM, ARAB, HAMIDREZA, RAFAATPANAH, HOOSHANG, AZANGOOKHIAVI, HASSAN, & DADPOUR, YALDA. (2012). EVALUATION OF THE EFFECTS OF CHRONIC PERIODONTITIS ON TLR-2 AND TLR-4 GENE EXPRESSION IN GINGIVAL TISSUES. JOURNAL OF MASHHAD DENTAL SCHOOL, 35(4 (79)), 297-306. SID. https://sid.ir/paper/74421/en

Vancouver: Copy

FATEMI KAZEM, RADVAR MEHRDAD, REZAEE ABDOLRAHIM, ARAB HAMIDREZA, RAFAATPANAH HOOSHANG, AZANGOOKHIAVI HASSAN, DADPOUR YALDA. EVALUATION OF THE EFFECTS OF CHRONIC PERIODONTITIS ON TLR-2 AND TLR-4 GENE EXPRESSION IN GINGIVAL TISSUES. JOURNAL OF MASHHAD DENTAL SCHOOL[Internet]. 2012;35(4 (79)):297-306. Available from: https://sid.ir/paper/74421/en

IEEE: Copy

KAZEM FATEMI, MEHRDAD RADVAR, ABDOLRAHIM REZAEE, HAMIDREZA ARAB, HOOSHANG RAFAATPANAH, HASSAN AZANGOOKHIAVI, and YALDA DADPOUR, “EVALUATION OF THE EFFECTS OF CHRONIC PERIODONTITIS ON TLR-2 AND TLR-4 GENE EXPRESSION IN GINGIVAL TISSUES,” JOURNAL OF MASHHAD DENTAL SCHOOL, vol. 35, no. 4 (79), pp. 297–306, 2012, [Online]. Available: https://sid.ir/paper/74421/en

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