Effects of thymoquinone in prevention of experimental contrastinduced nephropathy in rats

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Topaloslu Ulas Serkan; Sipahioglu Murat Hayri; Gunturk inayet; Akgun Hulya; Dogan Muhammet Ensar; Sonmez Gokhan; Elmali Ferhan; Yazici Cevat

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Journal: Iranian Journal of Basic Medical Sciences Year:2019 | Volume:22 | Issue:12 Page(s): 1432-1439

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Title

Effects of thymoquinone in prevention of experimental contrastinduced nephropathy in rats

Author(s)

Keywords

Contrast-inducednephropathy

Inflammation

Oxidative stress

Nigella sativa

Rat

Thymoquinone

Abstract

Objective(s): This study aimed to show the effects of Thymoquinone, which is known for its antioxidant, anti-inflammatory, and renal protective effects in contrast-induced nephropathy. Materials and Methods: This is an experimental study in Rats. 7 groups were included within the scope of our study: sham-vehicle (n=3), premedication-control (n=6), model (n=6), isolated Thymoquinone (n=3+3), low-dose Thymoquinone (n=6), and high-dose Thymoquinone (n=7). In addition to 48 hr of water deprivation, we pre-medicated the Rats with intra-peritoneal indomethacin and L-NAME administRation. After premedication, 12. 5 ml/kg dose of a high osmolar contrast agent-diatrizoat (Urografin %76) was administRated. Thymoquinone was administRated in two different doses of 1 mg/kg and 1. 75 mg/kg for four days intraperitoneally. Renal functions, histopathological differences, Oxidative stress parameters, and inflammatory indicators of Rats were evaluated at the end of the study. Results: Significant decreases were observed in levels of serum creatinine and serum BUN with lowdose Thymoquinone (1 mg/kg) administRation. In light microscopy, significantly less histopathological damage was observed in the low-dose Thymoquinone group compared to the contrast agent group. While high-dose Thymoquinone is accepted as ineffective biochemically, toxic evidence was identified histopathologically. There were no significant differences between M and TA groups for serum MDA and SOD levels, which were compared to evaluate Oxidative stress (P: 0. 99, P: 0. 98; respectively). TNF-α , iNOS, and NF-к B gene expressions were not significantly different between all groups (P: 0. 748, P: 0. 531, P: 0. 910; respectively). Conclusion: This experimental study has demonstRated for the first time the protective effect of the TQ substance for CIN in 1 mg/kg dose, in the accompaniment of biochemical and histopathological data in Rats.

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APA: Copy

Topaloslu, Ulas Serkan, Sipahioglu, Murat Hayri, Gunturk, inayet, Akgun, Hulya, Dogan, Muhammet Ensar, Sonmez, Gokhan, Elmali, Ferhan, & Yazici, Cevat. (2019). Effects of thymoquinone in prevention of experimental contrastinduced nephropathy in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(12), 1432-1439. SID. https://sid.ir/paper/744779/en

Vancouver: Copy

Topaloslu Ulas Serkan, Sipahioglu Murat Hayri, Gunturk inayet, Akgun Hulya, Dogan Muhammet Ensar, Sonmez Gokhan, Elmali Ferhan, Yazici Cevat. Effects of thymoquinone in prevention of experimental contrastinduced nephropathy in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(12):1432-1439. Available from: https://sid.ir/paper/744779/en

IEEE: Copy

Ulas Serkan Topaloslu, Murat Hayri Sipahioglu, inayet Gunturk, Hulya Akgun, Muhammet Ensar Dogan, Gokhan Sonmez, Ferhan Elmali, and Cevat Yazici, “Effects of thymoquinone in prevention of experimental contrastinduced nephropathy in rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 12, pp. 1432–1439, 2019, [Online]. Available: https://sid.ir/paper/744779/en

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