Expression of Transforming Growth Factor Beta in Giant-cell Granuloma of Jaws and Giant-cell Tumor of Bone

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SAGHRAVANIAN NASROLLAH; JAFARIAN AMIR HOSSEIN; GHAZI NARGES; Mozayeni Moein

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Journal: Journal of Mashhad Dental School Year:2018 | Volume:42 | Issue:3 Page(s): 221-228

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Information Journal Paper

Title

Expression of Transforming Growth Factor Beta in Giant-cell Granuloma of Jaws and Giant-cell Tumor of Bone

Author(s)

SAGHRAVANIAN NASROLLAH | JAFARIAN AMIR HOSSEIN | GHAZI NARGES | Mozayeni Moein | Issue Writer Certificate

Keywords

Giant-cell granulomaQ1

ImmunohistochemistryQ2

Transforming growth factor betaQ1

Abstract

Background and Objectives: Peripheral and central Giant-cell granulomas (PGCGs and CGCGs) and giant-cell tumor (GCT) of bone have similar histopathological features with different biological behavior. The aim of this study was to evaluate the expression of Transforming growth factor beta (TGF-β ) in these lesions by the help of Immunohistochemistry. Materials and Methods: In this study, 15 PGCGs, 15 CGCGs, and 10 GCTs were evaluated. The TGF-β immunoreactivity was assessed in mononuclear cells (MC) and multinucleated giant cells (MGC) of the studied groups. Data analysis was performed using Kruskal-Wallis and Dunn’ s tests. Results: There was a significant difference between three studied groups regarding both MCs and MGCs. The highest mean of TGF-β immunostaining was observed in GCTs and the lowest in PGCGs. In pairwise comparison of the studied groups, a significant difference was observed between PGCGs and GCTs considering both MCs and MGCs. Additionally, a significant deference was reported only in MCs between CGCGs and GCTs. Conclusion: The results may explain the different biological behavior and pathogenesis of these lesions despite the similarity of histopathologic features.

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APA: Copy

SAGHRAVANIAN, NASROLLAH, JAFARIAN, AMIR HOSSEIN, GHAZI, NARGES, & Mozayeni, Moein. (2018). Expression of Transforming Growth Factor Beta in Giant-cell Granuloma of Jaws and Giant-cell Tumor of Bone. JOURNAL OF MASHHAD DENTAL SCHOOL, 42(3 ), 221-228. SID. https://sid.ir/paper/74501/en

Vancouver: Copy

SAGHRAVANIAN NASROLLAH, JAFARIAN AMIR HOSSEIN, GHAZI NARGES, Mozayeni Moein. Expression of Transforming Growth Factor Beta in Giant-cell Granuloma of Jaws and Giant-cell Tumor of Bone. JOURNAL OF MASHHAD DENTAL SCHOOL[Internet]. 2018;42(3 ):221-228. Available from: https://sid.ir/paper/74501/en

IEEE: Copy

NASROLLAH SAGHRAVANIAN, AMIR HOSSEIN JAFARIAN, NARGES GHAZI, and Moein Mozayeni, “Expression of Transforming Growth Factor Beta in Giant-cell Granuloma of Jaws and Giant-cell Tumor of Bone,” JOURNAL OF MASHHAD DENTAL SCHOOL, vol. 42, no. 3 , pp. 221–228, 2018, [Online]. Available: https://sid.ir/paper/74501/en

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