A comparative study on the equine and camelid antivenoms upon cardiovascular changes induced with Hemiscorpius lepturus venom in rats

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Fatemikia Hossein; KAMYAB MOSTAFA; MOVAHED ALI; SADEGHI MEHDI; KIM EUIKYUNG; BEHDANI MAHDI; Mohammadpour Dounighi Naser; Shahrivar Mehrnaz; SEYEDIAN RAMIN

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Journal: Iranian Journal of Basic Medical Sciences Year:2019 | Volume:22 | Issue:12 Page(s): 1440-1444

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Title

A comparative study on the equine and camelid antivenoms upon cardiovascular changes induced with Hemiscorpius lepturus venom in rats

Author(s)

Keywords

Camelid antivenom

Cardiovascular

Envenomation

Equine antivenom

Hemiscorpius lepturus

Abstract

Objective(s): In this study, the neutralizing abilities of the equine and the recently introduced Camelid antivenoms on the hemodynamic parameters (inotropism, chronotropism, and arrhythmogenicity) were assessed following Envenomation by Hemiscorpius lepturus venom in rats. Materials and Methods: At first, the electrophoretic profiles of both products were obtained by using the SDS-PAGE method (12. 5%) and stained with Coomassie blue and silver nitrate. Secondly, different doses of the Camelid antivenom (10, 50, and 100 μ l) were given intravenously in 10 min before venom injection (400 μ g/rat). The neutralizing potencies of camelid and Equine antivenoms were measured by preincubation (100 μ l) with H. lepturus venom for 30 min at room temperature. Finally, equal amounts of the antivenoms were injected intravenously to observe the hemodynamic changes. Results: Based on the electrophoretic profile, it was evident that undesired proteins significantly decreased in Equine antivenom, owing to impurities. Pretreatment with the Camelid antivenom (100 μ l), neutralized the elevation of the mean arterial pressure evoked with scorpion venom injection (88. 15± 4. 56 versus 10. 2± 1. 23 percent at the 8th min). The Incubation of the venom and the Camelid antivenom counteracted the hemodynamic changes, but the equine product had no effect. The intravascular injection of the Equine antivenom transiently increased the mean arterial pressure as compared to the control (108. 67± 8. 63 mmHg versus 52. 67± 1. 93 mmHg at the 10th min). Conclusion: The most obvious finding emerging from this study was that the Camelid antivenom neutralized the hemodynamic changes in rats significantly, but in comparison, the Equine antivenom had just a minor ability.

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APA: Copy

Fatemikia, Hossein, KAMYAB, MOSTAFA, MOVAHED, ALI, SADEGHI, MEHDI, KIM, EUIKYUNG, BEHDANI, MAHDI, Mohammadpour Dounighi, Naser, Shahrivar, Mehrnaz, & SEYEDIAN, RAMIN. (2019). A comparative study on the equine and camelid antivenoms upon cardiovascular changes induced with Hemiscorpius lepturus venom in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(12), 1440-1444. SID. https://sid.ir/paper/745284/en

Vancouver: Copy

Fatemikia Hossein, KAMYAB MOSTAFA, MOVAHED ALI, SADEGHI MEHDI, KIM EUIKYUNG, BEHDANI MAHDI, Mohammadpour Dounighi Naser, Shahrivar Mehrnaz, SEYEDIAN RAMIN. A comparative study on the equine and camelid antivenoms upon cardiovascular changes induced with Hemiscorpius lepturus venom in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(12):1440-1444. Available from: https://sid.ir/paper/745284/en

IEEE: Copy

Hossein Fatemikia, MOSTAFA KAMYAB, ALI MOVAHED, MEHDI SADEGHI, EUIKYUNG KIM, MAHDI BEHDANI, Naser Mohammadpour Dounighi, Mehrnaz Shahrivar, and RAMIN SEYEDIAN, “A comparative study on the equine and camelid antivenoms upon cardiovascular changes induced with Hemiscorpius lepturus venom in rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 12, pp. 1440–1444, 2019, [Online]. Available: https://sid.ir/paper/745284/en

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