Efficacy and Safety of Zataria multiflora Boiss Essential Oil against Acute Toxoplasmosis in Mice

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MAHMOUDVAND HOSSEIN; TAVAKOLI KARESHK AMIR; Moradi Mohammad Nabi; MONZOTE FIDALGO Lianet; MIRBADIE Seyed Reza; NIAZI Massumeh; KHATAMI MEHRDAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF PARASITOLOGY Year:2020 | Volume:15 | Issue:1 Page(s): 22-30

Download Full-Text

View:

148

Download:

257

Cites:

Information Journal Paper

Title

Efficacy and Safety of Zataria multiflora Boiss Essential Oil against Acute Toxoplasmosis in Mice

Author(s)

Keywords

Prophylactic

Essential oil

Toxoplasma gondii

Treatment

Herbal medicines

Toxicity

Abstract

Background: Broad spectrums of pharmacological properties, including antimicrobial activity have been attributed to Zataria multiflora Boiss (Laminaceae). The in vivo efficacy and safety of Z. multiflora Essential oil (ZM-EO) were evaluated against acute toxoplasmosis caused by Toxoplasma gondii (Sarcocystidae) in mice. Methods: Z. multiflora (aerial parts) was obtained from the rural districts of Kerman city (Kerman Province) Southwestern Iran, in May of 2016. Male NMRI mice were orally treated with normal saline (control group) and ZM-EO at the doses of 0. 2 and 0. 4 mL/kg once a day for 14 d (8 mice in each group). On the 15th day, the mice were infected with 104 tachyzoites of T. gondii RH strain by intraperitoneal route. The mortality rate and parasite load were determined in the infected mice. Additionally, 24 mice were applied to examine the sub-acute Toxicity of ZM-EO at the above doses after Treatment during 14 d. Results: GC/MS analysis displayed that the key constituents were thymol (45. 4%), carvacrol (23%) and p-cymene (10. 6%), respectively. Overall, 100% mortality was observed on the 8th and 9th days in treated mice with the concentrations of 0. 2 and 0. 4 mL/kg, respectively. The mean number of tachyzoites in the mice treated with 0. 2 and 0. 4 mL/kg of ZM-EO were 189×104 and 76×104 cell/mL, respectively, meaningfully (P<0. 05) reduced compared with the control mice. Results also demonstrated that ZMEO had no important Toxicity on mice. Conclusion: The results demonstrated the efficacy of ZM-EO against acute toxoplasmosis. Nevertheless, supplementary surveys are mandatory to examine its precise effects, mainly immunomodulatory effect on toxoplasmosis.

Cites

No record.

References

No record.

Cite

APA: Copy

MAHMOUDVAND, HOSSEIN, TAVAKOLI KARESHK, AMIR, Moradi, Mohammad Nabi, MONZOTE FIDALGO, Lianet, MIRBADIE, Seyed Reza, NIAZI, Massumeh, & KHATAMI, MEHRDAD. (2020). Efficacy and Safety of Zataria multiflora Boiss Essential Oil against Acute Toxoplasmosis in Mice. IRANIAN JOURNAL OF PARASITOLOGY, 15(1), 22-30. SID. https://sid.ir/paper/745498/en

Vancouver: Copy

MAHMOUDVAND HOSSEIN, TAVAKOLI KARESHK AMIR, Moradi Mohammad Nabi, MONZOTE FIDALGO Lianet, MIRBADIE Seyed Reza, NIAZI Massumeh, KHATAMI MEHRDAD. Efficacy and Safety of Zataria multiflora Boiss Essential Oil against Acute Toxoplasmosis in Mice. IRANIAN JOURNAL OF PARASITOLOGY[Internet]. 2020;15(1):22-30. Available from: https://sid.ir/paper/745498/en

IEEE: Copy

HOSSEIN MAHMOUDVAND, AMIR TAVAKOLI KARESHK, Mohammad Nabi Moradi, Lianet MONZOTE FIDALGO, Seyed Reza MIRBADIE, Massumeh NIAZI, and MEHRDAD KHATAMI, “Efficacy and Safety of Zataria multiflora Boiss Essential Oil against Acute Toxoplasmosis in Mice,” IRANIAN JOURNAL OF PARASITOLOGY, vol. 15, no. 1, pp. 22–30, 2020, [Online]. Available: https://sid.ir/paper/745498/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops