Eryngium Billardieri Induces Apoptosis via Bax Gene Expression in Pancreatic Cancer Cells

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ROSHANRAVAN NEDA; Asgharian Parina; DARIUSHNEJAD HASSAN; MESRI ALAMDARI NAIMEH; MANSOORI BEHZAD; MOHAMMADI ALI; ALIPOUR SHAHRIAR; Barati Meisam; Ghavami Abed; ghorbanzadeh Vajihe; Aamazadeh Fatemeh; OSTADRAHIMI ALIREZA

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Journal: Advanced Pharmaceutical Bulletin Year:2018 | Volume:8 | Issue:4 Page(s): 667-674

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Title

Eryngium Billardieri Induces Apoptosis via Bax Gene Expression in Pancreatic Cancer Cells

Author(s)

Keywords

Adenocarcinoma

Bax

Cyclin D1

Eryngium

Pancreas

Abstract

Purpose: Pancreatic Adenocarcinoma has a high prevalence all over the world. Most of the therapeutic approaches failed as a result of tumor invasion and rapid metastasis. Several natural plants have been shown to have promising therapeutic effects. Thus, the aim of this study was to investigate the cytotoxic activity of Eryngium billardieri against PANC-1 cancer cell lines. Methods: Dimethylthiazole diphenyltetrazolium bromide assay (MTT assay) and flow cytometry were used to assess the cytotoxicity of E. billardieri extracts against PANC-1 cancer cell lines. Quantitative Polymerase Chain Reaction (qPCR) was conducted to investigate the expression levels of Bcl2-associated X protein (Bax) and Cyclin D1. Results: The results of the MTT assay showed that E. billardieri extracts had cytotoxic effects on PANC-1 cancer cell lines. Moreover, the findings from the gene expression confirmed the over expression of Bax, and under expression of Cyclin D1 following treatment with dichloromethane (DCM) and n-hexane (n-hex) extracts in cancer cells (P < 0. 05). Interestingly, the flow cytometry results showed that DCM and n-hex extracts of E. billardieri induced apoptosis in PANC-1 cancer cell lines. Conclusion: The results of this study demonstrated that DCM and n-hex extracts of E. billardieri significantly induce apoptosis by increasing Bax and decreasing Cyclin D1 mRNA expression. Therefore, E. billardieri may be regarded as a novel approach for treatment of pancreatic cancer as a result of its promising apoptotic and cytotoxic properties.

Cites

Survey on the use of Eryngium billardieri, Citrus aurantium and Foeniculum vulgare distillate wastewaters as a potential source antioxidant and antibacterial

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APA: Copy

ROSHANRAVAN, NEDA, Asgharian, Parina, DARIUSHNEJAD, HASSAN, MESRI ALAMDARI, NAIMEH, MANSOORI, BEHZAD, MOHAMMADI, ALI, ALIPOUR, SHAHRIAR, Barati, Meisam, Ghavami, Abed, ghorbanzadeh, Vajihe, Aamazadeh, Fatemeh, & OSTADRAHIMI, ALIREZA. (2018). Eryngium Billardieri Induces Apoptosis via Bax Gene Expression in Pancreatic Cancer Cells. ADVANCED PHARMACEUTICAL BULLETIN, 8(4), 667-674. SID. https://sid.ir/paper/745838/en

Vancouver: Copy

ROSHANRAVAN NEDA, Asgharian Parina, DARIUSHNEJAD HASSAN, MESRI ALAMDARI NAIMEH, MANSOORI BEHZAD, MOHAMMADI ALI, ALIPOUR SHAHRIAR, Barati Meisam, Ghavami Abed, ghorbanzadeh Vajihe, Aamazadeh Fatemeh, OSTADRAHIMI ALIREZA. Eryngium Billardieri Induces Apoptosis via Bax Gene Expression in Pancreatic Cancer Cells. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2018;8(4):667-674. Available from: https://sid.ir/paper/745838/en

IEEE: Copy

NEDA ROSHANRAVAN, Parina Asgharian, HASSAN DARIUSHNEJAD, NAIMEH MESRI ALAMDARI, BEHZAD MANSOORI, ALI MOHAMMADI, SHAHRIAR ALIPOUR, Meisam Barati, Abed Ghavami, Vajihe ghorbanzadeh, Fatemeh Aamazadeh, and ALIREZA OSTADRAHIMI, “Eryngium Billardieri Induces Apoptosis via Bax Gene Expression in Pancreatic Cancer Cells,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 8, no. 4, pp. 667–674, 2018, [Online]. Available: https://sid.ir/paper/745838/en

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