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Title

Diabetes Mellitus: Findings from 20 Years of the Tehran Lipid and Glucose Study

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Abstract

 Context: We summarized findings from Tehran Lipid and Glucose Study (TLGS) about different aspects of type 2 Diabetes (T2D) over the span of nearly 2 decades. Evidence Acquisition: A review was undertaken to retrieve papers related to all aspects of T2D from the earliest date available up to January 30, 2018. Results: An annual crude incidence rate of 10 per 1000 person-years of follow-up was found for T2D in adult participants. Overall incidence rate of pre-Diabetes/T2D was 36. 3 per 1000 person-years or about 1% each year among youth. Diabetes was associated with increased risk of CVD[hazard ratio (HR): 1. 86, 95% confidence interval (95% CI): 1. 57-2. 27] and mortality [HR: 2. 56; 95% CI: 2. 08-3. 16] in the total population. Compared with non-diabetic men and women, their diabetic counterparts survived 1. 4 and 0. 7 years shorter, respectively, during 15 years of follow-up. Wrist circumference, hyperinsulinaemia, 25-hydroxy vitamin D and increase in alanin aminotranferase provided incremental prognostic information beyond the traditional risk factors for incident T2D in adults. Using decision tree algorithms, a number of high risk groups were found for incident T2D. A probability of 84% was found for incidence of T2D among a group of men with fasting plasma glucose (FPG) > 5. 3 mmol/L and waist to height ratio (WHtR) > 0. 56, and women with FPG > 5. 2 mmol/L and WHtR > 0. 56. Conclusions: Original TLGS studies have contributed greatly to clarify important evidence regarding the epidemiology and risk factors for T2D among Iranian population.

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    APA: Copy

    RAMEZANKHANI, AZRA, HARATI, HADI, BOZORGMANESH, MOHAMMADREZA, TOHIDI, MARYAM, KHALILI, DAVOOD, AZIZI, FEREIDOUN, & HADAEGH, FARZAD. (2018). Diabetes Mellitus: Findings from 20 Years of the Tehran Lipid and Glucose Study. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 16(4 (Suppl.)), 0-0. SID. https://sid.ir/paper/746472/en

    Vancouver: Copy

    RAMEZANKHANI AZRA, HARATI HADI, BOZORGMANESH MOHAMMADREZA, TOHIDI MARYAM, KHALILI DAVOOD, AZIZI FEREIDOUN, HADAEGH FARZAD. Diabetes Mellitus: Findings from 20 Years of the Tehran Lipid and Glucose Study. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2018;16(4 (Suppl.)):0-0. Available from: https://sid.ir/paper/746472/en

    IEEE: Copy

    AZRA RAMEZANKHANI, HADI HARATI, MOHAMMADREZA BOZORGMANESH, MARYAM TOHIDI, DAVOOD KHALILI, FEREIDOUN AZIZI, and FARZAD HADAEGH, “Diabetes Mellitus: Findings from 20 Years of the Tehran Lipid and Glucose Study,” INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 16, no. 4 (Suppl.), pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/746472/en

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