Comparison of BRCA1 Expression between Triple-Negative and Luminal Breast Tumors (SHORT COMMUNICATION)

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Darbeheshti Farzaneh; IZADI PANTEA; EMAMI RAZAVI AMIR NADER; YEKANINEJAD MIR SAEED; TAVAKKOLY BAZZAZ JAVAD

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Journal: Iranian Biomedical Journal Year:2018 | Volume:22 | Issue:3 Page(s): 210-214

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Title

Comparison of BRCA1 Expression between Triple-Negative and Luminal Breast Tumors (SHORT COMMUNICATION)

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Keywords

Breast cancer

BRCA1

Triple-negative breast neoplasm

Abstract

Background: Previous studies have suggested that BRCA1 dysregulation has been shown to have a role in triplenegative phenotypic manifestation. However, differences of BRCA1 expression, as a tumor suppressor gene, have rarely been investigated between luminal and triple-negative breast tumors. Therefore, the present study attempted to compare the BRCA1 expression in triple-negative with luminal breast tumors and its association with the clinicopathologic characteristics of patients. Methods: BRCA1 expression was evaluated by real-time PCR in 26 triple-negative and 27 luminal breast tumors. Results: The results revealed that there is a high frequency of BRCA1 underexpression in both triple-negative and luminal breast tumors. The BRCA1 underexpression was related to young age at diagnosis, lymph node involvement, and grade І І І tumors. Conclusion: The observations suggest that decreased BRCA1 expression, regardless of tumor subtype, has a general role in breast malignancy and associated with poor prognostic features in breast tumors.

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APA: Copy

Darbeheshti, Farzaneh, IZADI, PANTEA, EMAMI RAZAVI, AMIR NADER, YEKANINEJAD, MIR SAEED, & TAVAKKOLY BAZZAZ, JAVAD. (2018). Comparison of BRCA1 Expression between Triple-Negative and Luminal Breast Tumors (SHORT COMMUNICATION). IRANIAN BIOMEDICAL JOURNAL, 22(3), 210-214. SID. https://sid.ir/paper/746534/en

Vancouver: Copy

Darbeheshti Farzaneh, IZADI PANTEA, EMAMI RAZAVI AMIR NADER, YEKANINEJAD MIR SAEED, TAVAKKOLY BAZZAZ JAVAD. Comparison of BRCA1 Expression between Triple-Negative and Luminal Breast Tumors (SHORT COMMUNICATION). IRANIAN BIOMEDICAL JOURNAL[Internet]. 2018;22(3):210-214. Available from: https://sid.ir/paper/746534/en

IEEE: Copy

Farzaneh Darbeheshti, PANTEA IZADI, AMIR NADER EMAMI RAZAVI, MIR SAEED YEKANINEJAD, and JAVAD TAVAKKOLY BAZZAZ, “Comparison of BRCA1 Expression between Triple-Negative and Luminal Breast Tumors (SHORT COMMUNICATION),” IRANIAN BIOMEDICAL JOURNAL, vol. 22, no. 3, pp. 210–214, 2018, [Online]. Available: https://sid.ir/paper/746534/en

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