Vascular Mimicry Expression in Invasive Ductal Carcinoma; A New Technique for Prospect of Aggressiveness

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Jafarian Amir Hossei; Kooshkiforooshani Melika; Rasoliostadi Abdolshakor; MOHAMADIAN ROSHAN NEMA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF PATHOLOGY (IJP) Year:2019 | Volume:14 | Issue:3 Page(s): 232-235

Download Full-Text

View:

116

Download:

Cites:

Information Journal Paper

Title

Vascular Mimicry Expression in Invasive Ductal Carcinoma; A New Technique for Prospect of Aggressiveness

Author(s)

Jafarian Amir Hossei | Kooshkiforooshani Melika | Rasoliostadi Abdolshakor | MOHAMADIAN ROSHAN NEMA | Issue Writer Certificate

Keywords

Vascular mimicry

Breast cancer

Immunohistochemistry staining

Abstract

Background & Objective: In vascular (vasculogenic) mimicry (VM), tumoral cells mimic the endothelial cells and form the extracellular matrix-rich tubular networks. It has been proposed that VM is more extensive in aggressive tumors. This study was designed to investigate the rate of VM expression in the stromal cells of invasive ductal carcinoma (IDC) and to find its relationship with other clinicopathological factors. Methods: In this cross-sectional study, 120 patients with histopathologic diagnosis of IDC who received mastectomy were included. The VM expression was determined by immunohistochemistry (IHC). The clinicopathologic data including age, tumor size, histological grade, clinical stage, axillary lymph node metastasis, hormonal receptors, and survival were documented. Results: The mean (± SD) age of the patients was 51 (± 13. 83) years old. The stromal VM expression was detected in 16 of 120 patients (13. 3%). Twelve specimens (75%) of positive VM expression group had grade 3 which was higher than negative VM expression group (9 cases, 8. 65%; P<0. 001). The VM expression showed statistically significant relationship with higher histologic grade higher clinical stage (stage 3) of the tumor (62. 5% vs. 87%; P=0. 003), the presence of axillary lymph node metastasis (95. 6% vs. 55. 8%; P<0. 001), and positive HER-2 (100% vs. 31. 1%; P<0. 001); but not estrogen receptor (ER) or progesterone receptor (PR). However, age, tumor size and mortality rate were not significantly different among the patients with and without VM expression. Conclusion: The stromal VM expression showed significant relationship with higher stage and grade of the tumor and the presence of nodal metastasis. The VM expression in IDC can be used as a marker for tumor aggressiveness.

Cites

Relationship between Computed Tompgraphy Pulmonary Angiography Findings and Clinical Findings Based on Wells Score in Acute Pulmonary Thromboembolism

References

No record.

Cite

APA: Copy

Jafarian, Amir Hossei, Kooshkiforooshani, Melika, Rasoliostadi, Abdolshakor, & MOHAMADIAN ROSHAN, NEMA. (2019). Vascular Mimicry Expression in Invasive Ductal Carcinoma; A New Technique for Prospect of Aggressiveness. IRANIAN JOURNAL OF PATHOLOGY (IJP), 14(3), 232-235. SID. https://sid.ir/paper/747382/en

Vancouver: Copy

Jafarian Amir Hossei, Kooshkiforooshani Melika, Rasoliostadi Abdolshakor, MOHAMADIAN ROSHAN NEMA. Vascular Mimicry Expression in Invasive Ductal Carcinoma; A New Technique for Prospect of Aggressiveness. IRANIAN JOURNAL OF PATHOLOGY (IJP)[Internet]. 2019;14(3):232-235. Available from: https://sid.ir/paper/747382/en

IEEE: Copy

Amir Hossei Jafarian, Melika Kooshkiforooshani, Abdolshakor Rasoliostadi, and NEMA MOHAMADIAN ROSHAN, “Vascular Mimicry Expression in Invasive Ductal Carcinoma; A New Technique for Prospect of Aggressiveness,” IRANIAN JOURNAL OF PATHOLOGY (IJP), vol. 14, no. 3, pp. 232–235, 2019, [Online]. Available: https://sid.ir/paper/747382/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops