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Information Journal Paper

Title

LEPTIN, HEART DISEASE AND EXERCISE

Pages

  65-77

Keywords

Abstract

 Obesity is a complex disorder characterized by the accumulation of excess adipose tissue. Discovery of the hormone LEPTIN in 1994 catalyzed the field of obesity research by demonstrating the existence of an afferent hormonal signal from adipose tissue to the central nervous system. LEPTIN the product of the ob gene is a proteohormone with a molecular mass of 16 kDa that is thought to play a key role in the regulation of body weight. LEPTIN increases energy expenditure by enhancing sympathic nervous activity and lypolysis. It also suppresses appetite by acting on the hypothalamus. In recent years the potential participation of LEPTIN has been reported to increase arterial pressure and heart rate by peripherally or centrally mediated mechanisms. The finding that LEPTIN is linked to heart disease risk, strongly suggests that fat may be important in heart disease risk. LEPTIN deficiency and resistance to the effects of LEPTIN are each associated with weight gain. LEPTIN resistance is much more common than LEPTIN deficiency in human obesity. There are receptors for LEPTIN on the endothelium and on vascular smooth muscle cells. Accordingly, LEPTIN can exert receptor mediated influence on vessel tone and growth. In cell culture, LEPTIN stimulates vascular smooth muscle proliferation. vascular calcification is also accelerate by LEPTIN in experimental models.Additionally, LEPTIN induces oxidative stress in endothelial cells. Accordingly, it is possible that the high level of LEPTIN observed in obesity could contribute to its adverse effects on cardiovascular health. Diet and EXERCISE has been shown to reduce LEPTIN levels regardless of weight loss. EXERCISE training induced reduction in LEPTIN levels have been attributed to alterations in energy balance, improvements in insulin sensitivity alterations in lipid metabolism, and unknown factors. This article considers LEPTIN function and the impact that EXERCISE has on blood LEPTIN concentrations.

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    APA: Copy

    HOJATI, ZAHRA, RAHMANINIA, FARHAD, RAHNAMA, NADER, & SOLTANI, BAHRAM. (2008). LEPTIN, HEART DISEASE AND EXERCISE. JOURNAL OF MOVEMENT SCIENCE & SPORTS, 6(11), 65-77. SID. https://sid.ir/paper/74770/en

    Vancouver: Copy

    HOJATI ZAHRA, RAHMANINIA FARHAD, RAHNAMA NADER, SOLTANI BAHRAM. LEPTIN, HEART DISEASE AND EXERCISE. JOURNAL OF MOVEMENT SCIENCE & SPORTS[Internet]. 2008;6(11):65-77. Available from: https://sid.ir/paper/74770/en

    IEEE: Copy

    ZAHRA HOJATI, FARHAD RAHMANINIA, NADER RAHNAMA, and BAHRAM SOLTANI, “LEPTIN, HEART DISEASE AND EXERCISE,” JOURNAL OF MOVEMENT SCIENCE & SPORTS, vol. 6, no. 11, pp. 65–77, 2008, [Online]. Available: https://sid.ir/paper/74770/en

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