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Information Journal Paper

Title

Correlation of quinolone-resistance, qnr genes and integron carriage in multidrug-resistant community isolates of Klebsiella spp.

Pages

  1387-1391

Abstract

 Objective(s): Plasmid-mediated quinolone resistance (PMQR) determinants and Integrons have a considerable contribution to bacterial drug resistance in gram-negative pathogens. We studied the prevalence of PMQR genes and Integron carriage in multidrug-resistant Community isolates of Klebsiella spp. Materials and Methods: Two hundred and fifty Klebsiella spp. isolates were collected from outpatient specimens between August 2015 and October 2017 in Yazd central Laboratory, Iran. Antibiotic susceptibility was determined against 17 antibiotics and minimum inhibitory concentration (MIC) of ciprofloxacin was measured by E-test. Polymerase chain reaction (PCR) was employed for detection of qnrA, qnrB, qnrS, aac(6’ )-Ib-cr, oqxAB and qepA genes. Results: Disc diffusion results showed that 17 isolates (6. 8%) were multidrug resistant (MDR), two of which were Klebsiella oxytoca and 15 were Klebsiella pneumoniae. MIC measurements revealed 11 ciprofloxacin-resistant isolates (including the two K. oxytoca), three intermediately-resistant and three ciprofloxacin-susceptible isolates. All ciprofloxacin-resistant and intermediately-resistant isolates carried at least one and up to four PMQR genes. The most prevalent PMQR gene was oqxAB (93. 75%) followed by aac(6’ )-ib-cr (50. 0%), qnrB (25. 0%) and qnrS (18. 75%) but qnrA and qepA were not detected. Class 1 Integron was observed in 14 (82. 3%) isolates including nine ciprofloxacinresistant, two intermediately-resistant, and three susceptible isolates. Class 2 and 3 Integrons were not observed. Conclusion: Presence of MDR, multiple PMQR determinants as well as class 1 Integron in Community isolates of Klebsiella spp. can be an important source of transmission of these opportunistic pathogens.

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    APA: Copy

    Malek Jamshidi, Mohammad Reza, ZANDI, HENGAMEH, & EFTEKHAR, FERESHTEH. (2019). Correlation of quinolone-resistance, qnr genes and integron carriage in multidrug-resistant community isolates of Klebsiella spp.. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(12), 1387-1391. SID. https://sid.ir/paper/747870/en

    Vancouver: Copy

    Malek Jamshidi Mohammad Reza, ZANDI HENGAMEH, EFTEKHAR FERESHTEH. Correlation of quinolone-resistance, qnr genes and integron carriage in multidrug-resistant community isolates of Klebsiella spp.. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(12):1387-1391. Available from: https://sid.ir/paper/747870/en

    IEEE: Copy

    Mohammad Reza Malek Jamshidi, HENGAMEH ZANDI, and FERESHTEH EFTEKHAR, “Correlation of quinolone-resistance, qnr genes and integron carriage in multidrug-resistant community isolates of Klebsiella spp.,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 12, pp. 1387–1391, 2019, [Online]. Available: https://sid.ir/paper/747870/en

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