Captopril Attenuates Diazinon-Induced Oxidative Stress: A Subchronic Study in Rats

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Karimani Asieh; Mamashkhani Yasaman; MOGHADAM JAFARI AMIR; Akbarabadi Masoumeh; HEIDARPOUR MOHAMMAD

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Journal: IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS) Year:2018 | Volume:43 | Issue:5 Page(s): 514-522

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Title

Captopril Attenuates Diazinon-Induced Oxidative Stress: A Subchronic Study in Rats

Author(s)

Keywords

Captopril

Diazinon

Lipid peroxidation

Antioxidants

Abstract

Background: Diazinon (DZN) is an organophosphate pesticide commonly used for pest control in agriculture. It may engender a variety of negative effects in non-target species, including humans and animals. The objective of the present study was to evaluate the ameliorative properties of Captopril (CAP), as a thiol containing an angiotensin-converting enzyme inhibitor, against DZN-induced oxidative stress. Methods: Twenty-eight male Wistar rats were divided randomly into 4 groups. All the rats were treated orally via gavage once a day for 7 weeks: control (corn oil), CAP (10 mg/kg), DZN (10 mg/kg), and CAP+DZN combination (as mentioned above). Oxidative stress indices in blood serum, liver and kidney homogenates (malondialdehyde [MDA], total thiol groups, and total antioxidant capacity), and erythrocyte hemolysis (superoxide dismutase [SOD] and glutathione peroxidase) were evaluated. Statistical analysis was performed using GraphPad Prism software, version 6. 0 (GraphPad, San Diego, CA, USA), by ANOVA, followed by the Tukey post hoc analysis. Results: The MDA content and SOD activity increased significantly in the DZN group compared with those in the control group. Treatment with CAP in the DZN-exposed group significantly decreased (P<0. 05) the MDA concentration and the SOD activity. The total thiol groups were decreased in the DZN group and elevated again by CAP treatment. Conclusion: The co-administration of CAP and DZN was able to attenuate Lipid peroxidation and enzyme changes caused by DZN.

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APA: Copy

Karimani, Asieh, Mamashkhani, Yasaman, MOGHADAM JAFARI, AMIR, Akbarabadi, Masoumeh, & HEIDARPOUR, MOHAMMAD. (2018). Captopril Attenuates Diazinon-Induced Oxidative Stress: A Subchronic Study in Rats. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 43(5), 514-522. SID. https://sid.ir/paper/748799/en

Vancouver: Copy

Karimani Asieh, Mamashkhani Yasaman, MOGHADAM JAFARI AMIR, Akbarabadi Masoumeh, HEIDARPOUR MOHAMMAD. Captopril Attenuates Diazinon-Induced Oxidative Stress: A Subchronic Study in Rats. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2018;43(5):514-522. Available from: https://sid.ir/paper/748799/en

IEEE: Copy

Asieh Karimani, Yasaman Mamashkhani, AMIR MOGHADAM JAFARI, Masoumeh Akbarabadi, and MOHAMMAD HEIDARPOUR, “Captopril Attenuates Diazinon-Induced Oxidative Stress: A Subchronic Study in Rats,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 43, no. 5, pp. 514–522, 2018, [Online]. Available: https://sid.ir/paper/748799/en

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