THE ROLE OF CA2+ AND K+ CHANNELS IN REGULATION THE PATTERN OF SPONTANEOUS ACTIVITY IN CEREBELLAR PURKINJE CELLS

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HAGH DOUST YAZDI H.; JANAHMADI M.; BEHZADI G.

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Journal: Physiology and Pharmacology Year:2006 | Volume:9 | Issue:2 Page(s): 107-114

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Title

THE ROLE OF CA2+ AND K+ CHANNELS IN REGULATION THE PATTERN OF SPONTANEOUS ACTIVITY IN CEREBELLAR PURKINJE CELLS

Author(s)

HAGH DOUST YAZDI H. | JANAHMADI M. | BEHZADI G. | Issue Writer Certificate

Keywords

PURKINJE NEURONSQ4

FIRING PATTERNQ4

BRAIN SLICESQ4

INTRACELLULAR RECORDINGQ3

APAMINQ4

DTXQ4

Abstract

The cerebellum is responsible for coordination of movement and maintenance of balance. Purkinje cells (PCs) are principle neurons of anatomically well defined cerebellar modules and it is proposed that coordination of movement is achieved by encoding timing signals in the rate of firing and pattern of activity these cells. Understanding of cerebellar timing requires an appreciation of the intrinsic firing behavior of PCs.In order to determine how changes in membrane biophysics including Ca2+ and K+ channels activity influence the electrical activity of PURKINJE NEURONS, INTRACELLULAR RECORDING from acutely prepared cerebellar slices was performed. PCs fired spontaneously bursts of calcium or sodium-calcium spikes which were separated by quiescent- interburst periods. They also showed long lasting bursts and long silence periods. Cadmium, a wild range of Ca2+ channels blocker, resulted in an elimination of calcium spikes while left the sodium aetion potential intact. Blockade potassium channels by 4-AP and TEA improved the spontaneous activity and limited silence period. 4-AP also prolongedthe burst and interburst period and decreased the firing frequency. On the other hand, APAMIN, a neurotoxin from bee venom, known to selectively block small conductance of calcium activated potassium channels (SK), and a-dendrotoxin (DTX), specific blocker of Kv1 channels, shortened the burst and interburst duration. DTX and APAMIN also increased the frequency of burst occurrence and DTX decreases intraburst frequency.In conclusion, with the data presented it is fair to state that intrinsic membrane properties including K+ channels activity, seem to play important roles in the formation of FIRING PATTERNs in PURKINJE NEURONS.

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APA: Copy

HAGH DOUST YAZDI, H., JANAHMADI, M., & BEHZADI, G.. (2006). THE ROLE OF CA2+ AND K+ CHANNELS IN REGULATION THE PATTERN OF SPONTANEOUS ACTIVITY IN CEREBELLAR PURKINJE CELLS. PHYSIOLOGY AND PHARMACOLOGY, 9(2), 107-114. SID. https://sid.ir/paper/74927/en

Vancouver: Copy

HAGH DOUST YAZDI H., JANAHMADI M., BEHZADI G.. THE ROLE OF CA2+ AND K+ CHANNELS IN REGULATION THE PATTERN OF SPONTANEOUS ACTIVITY IN CEREBELLAR PURKINJE CELLS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2006;9(2):107-114. Available from: https://sid.ir/paper/74927/en

IEEE: Copy

H. HAGH DOUST YAZDI, M. JANAHMADI, and G. BEHZADI, “THE ROLE OF CA2+ AND K+ CHANNELS IN REGULATION THE PATTERN OF SPONTANEOUS ACTIVITY IN CEREBELLAR PURKINJE CELLS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 9, no. 2, pp. 107–114, 2006, [Online]. Available: https://sid.ir/paper/74927/en

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