EFFECT OF FINASTRIDE, AN INHIBITOR OF 5 A-REDUCTASE, ON PHYSICAL DEPENDENCE INDUCED BY CHRONIC ADMINISTRATION OF MORPHINE IN MALE RATS

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VERDI J.; AHMADIANI A.

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Journal: Physiology and Pharmacology Year:2006 | Volume:9 | Issue:2 Page(s): 159-162

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Title

EFFECT OF FINASTRIDE, AN INHIBITOR OF 5 A-REDUCTASE, ON PHYSICAL DEPENDENCE INDUCED BY CHRONIC ADMINISTRATION OF MORPHINE IN MALE RATS

Author(s)

VERDI J. | AHMADIANI A. | Issue Writer Certificate

Keywords

5 ALPHA-REDUCTASEQ4

FINASTRIDEQ3

DEPENDENCEQ3

MORPHINEQ4

Abstract

Tolerance and DEPENDENCE are two main problems which have limited MORPHINE administration as an analgesic drug. Following acute and chronic administration of MORPHINE changes in the level of sex steroids and the activity of calcium channels are reported. The enzyme 5 a-reductase plays a pivotal role in the conversion of testosterone to dehydrotestosterone and therefore reduces the testosterone levels. In this investigation, we tried to study the effects of acute and chronic administration of FINASTRIDE (inhibitor of 5 a-reductase) on MORPHINE DEPENDENCE in the male rats. MORPHINE dependency was induced by the intraperitoneal (i.p.) injection of MORPHINE for 4 days (20, 30, 40 and 40 mg/kg respectively at days 1-4). Physical DEPENDENCE to MORPHINE was observed following administration of naloxone (2 mg/kg-i.p., day 5).Acute administration of FINASTRIDE at 5th day (5 mg/kg-i.p., twice with 2 hours interval), decreased all withdrawal signs significantly, while the administration the vehicle, caster oil, did not. Chronic administration of FINASTRIDE prior to daily administration of MORPHINE during days 1-4 significantly decreased all withdrawal signs at the day 5. This finding indicates that inhibition of testosterone metabolism in the CNS using FINASTRIDE may be able to modulate the withdrawal sings expression and prevents the development of physical DEPENDENCE.

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APA: Copy

VERDI, J., & AHMADIANI, A.. (2006). EFFECT OF FINASTRIDE, AN INHIBITOR OF 5 A-REDUCTASE, ON PHYSICAL DEPENDENCE INDUCED BY CHRONIC ADMINISTRATION OF MORPHINE IN MALE RATS. PHYSIOLOGY AND PHARMACOLOGY, 9(2), 159-162. SID. https://sid.ir/paper/74931/en

Vancouver: Copy

VERDI J., AHMADIANI A.. EFFECT OF FINASTRIDE, AN INHIBITOR OF 5 A-REDUCTASE, ON PHYSICAL DEPENDENCE INDUCED BY CHRONIC ADMINISTRATION OF MORPHINE IN MALE RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2006;9(2):159-162. Available from: https://sid.ir/paper/74931/en

IEEE: Copy

J. VERDI, and A. AHMADIANI, “EFFECT OF FINASTRIDE, AN INHIBITOR OF 5 A-REDUCTASE, ON PHYSICAL DEPENDENCE INDUCED BY CHRONIC ADMINISTRATION OF MORPHINE IN MALE RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 9, no. 2, pp. 159–162, 2006, [Online]. Available: https://sid.ir/paper/74931/en

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