مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

153
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

96
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Significance of epithelial-to-mesenchymal transition inducing transcription factors in predicting distance metastasis and survival in patients with colorectal cancer: A systematic review and meta-analysis

Pages

  0-0

Abstract

 Background: The clinical relevance of epithelial‑ to‑ mesenchymal transition (EMT) in Colorectal cancer (CRC) progression has been highlighted over the last decade. Several EMT‑ inducing transcription factors (EMT‑ TFs) have been implicated in the regulation of EMT, including Twist, Snail1, Slug, ZEB1, and ZEB2. Here, this meta‑ analysis aimed to predict the risk of distance metastasis and overall survival in CRC patients with high expression of EMT‑ TFs. Materials and Methods: All eligible studies were searched in PubMed, Scopus, and Web of Science databases. The search was carried out to include literatures published as late as September 1, 2018. In overall, 16 studies that investigated the relationship between EMT‑ TFs with distance metastasis and survival in CRC patients were included. In meta‑ analysis, a pooled hazard ratio (HR) and odds ratio (OR) were estimated for associations. Results: The results of this review indicated that expressions of all EMT‑ TFs are significantly correlated with poor overall survival in CRC. Moreover, there are a significant association between Twist (OR, 1. 46; 95% confidence interval [CI], 1. 03– 2. 09), Slug (OR, 3. 43; 95% CI, 1. 98– 5. 93), and ZEB2 (OR, 2. 42; 95% CI, 1. 09– 5. 40) expression with distance metastatic in CRC patients. Conclusion: These findings suggest that the overexpression of EMT‑ TFs plays a key role in increasing the risk of distance metastasis as well as decreasing overall survival in CRC patients.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    AHMADIANKIA, NAGHMEH, & KHOSRAVI, AHMAD. (2020). Significance of epithelial-to-mesenchymal transition inducing transcription factors in predicting distance metastasis and survival in patients with colorectal cancer: A systematic review and meta-analysis. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 25(6), 0-0. SID. https://sid.ir/paper/749434/en

    Vancouver: Copy

    AHMADIANKIA NAGHMEH, KHOSRAVI AHMAD. Significance of epithelial-to-mesenchymal transition inducing transcription factors in predicting distance metastasis and survival in patients with colorectal cancer: A systematic review and meta-analysis. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2020;25(6):0-0. Available from: https://sid.ir/paper/749434/en

    IEEE: Copy

    NAGHMEH AHMADIANKIA, and AHMAD KHOSRAVI, “Significance of epithelial-to-mesenchymal transition inducing transcription factors in predicting distance metastasis and survival in patients with colorectal cancer: A systematic review and meta-analysis,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 25, no. 6, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/749434/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button