مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

168
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

119
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Changes of miR-130a and ET-1 and Their Predictive Value for In-Stent Restenosis after Percutaneous Coronary Intervention

Pages

  463-471

Abstract

 Background: To explore the changes of miR-130a and endothelin-1 (ET-1) and their predictive value for instent restenosis (ISR) after percutaneous coronary intervention (PCI). Methods: Overall, 253 patients with Coronary heart disease (CHD) treated with PCI in Lianshui County People's Hospital, Huaian, China from April 2013 to May 2016 were selected. The changes of miR-130a and ET-1 levels before and after PCI were compared. The predictive value of miR-130a and ET-1 for ISR was analyzed by receiver operating characteristic (ROC) curves, and the correlation between ISR and miR-130a, ET-1 was analyzed by Kaplan-Meier (K-M) curve. The risk factors of ISR in CHD patients were evaluated by logistics regression analysis. Results: The postoperative levels of miR-130a and ET-1 were significantly increased (P<0. 05). The levels of miR-130a and ET-1 in peripheral blood of patients with ISR were higher than those in patients without ISR (P<0. 05). The ROC curves showed that the area under curve (AUC), sensitivity, specificity and critical value of miR-130a in predicting ISR were respectively 0. 912, 92. 02%, 73. 47%, 1. 457 pmol/L, and those of ET-1 were 0. 814, 87. 63%, 63. 27%, 2. 245 pmol/L, respectively. The K-M curve showed that the incidence of ISR in patients with high expression of miR-130a or ET-1 was significantly higher than that in patients with low expression (P<0. 05). miR-130a and ET-1 were independent risk factors for ISR (P<0. 05). Conclusion: miR-130a and ET-1 have high predictive value for ISR after PCI and are independent risk factors for CHD patients, which are worthy of clinical application.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    LIU, Hongliang, QIAN, Hao, MA, Junlin, DAI, Qiming, & JI, Mingyue. (2020). Changes of miR-130a and ET-1 and Their Predictive Value for In-Stent Restenosis after Percutaneous Coronary Intervention. IRANIAN JOURNAL OF PUBLIC HEALTH, 49(3), 463-471. SID. https://sid.ir/paper/749440/en

    Vancouver: Copy

    LIU Hongliang, QIAN Hao, MA Junlin, DAI Qiming, JI Mingyue. Changes of miR-130a and ET-1 and Their Predictive Value for In-Stent Restenosis after Percutaneous Coronary Intervention. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2020;49(3):463-471. Available from: https://sid.ir/paper/749440/en

    IEEE: Copy

    Hongliang LIU, Hao QIAN, Junlin MA, Qiming DAI, and Mingyue JI, “Changes of miR-130a and ET-1 and Their Predictive Value for In-Stent Restenosis after Percutaneous Coronary Intervention,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 49, no. 3, pp. 463–471, 2020, [Online]. Available: https://sid.ir/paper/749440/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button