The Increased RNase Activity of IRE1α in PBMCs from Patients with Rheumatoid Arthritis

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Ahmadiany Mahdieh; Alavi Samani Mahshid; HASHEMI ZAHRA; MOOSAVI MOHAMMAD AMIN; RAHMATI MARVEH

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Journal: Advanced Pharmaceutical Bulletin Year:2019 | Volume:9 | Issue:3 Page(s): 505-509

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Title

The Increased RNase Activity of IRE1α in PBMCs from Patients with Rheumatoid Arthritis

Author(s)

Keywords

Endoplasmic reticulum stress

Inositol-requiring enzyme 1

IRE1-dependent decay

microRNA

Rheumatoid arthritis

Abstract

Purpose: Despite recent advances in the diagnosis and treatment of Rheumatoid arthritis (RA), this inflammatory disease remains a challenge to patients and physicians. Recent evidence highlights the contribution of endoplasmic reticulum (ER) stress in the pathogenesis and treatment of RA. Herein, we study the expression of the ER stress sensor Inositol-requiring enzyme 1α (IRE1α ), as well as XBP1 splicing and the regulated IRE1-dependent decay (RIDD), in peripheral blood mononuclear cells (PBMCs) from patients with RA compared with healthy controls. Methods: The PBMCs from blood samples of RA patients and healthy volunteers were isolated by a density gradient centrifugation method using Ficoll. The gene expression levels of GRP78/ Bip, IRE1, XBP1s, micro-RNAs (miRNAs) were evaluated by real-time PCR. Results: The expression of GRP78, IRE1, and XBP1s were increased in PBMCs of RA patients compared with healthy controls. We further show that the RIDD targets (miRNA-17,-34a,-96, and-125b) were downregulated in RA samples. Conclusion: This study can expand our knowledge on the importance of RNase activity of IRE1α in RA and may offer new potentials for developing novel diagnostic and/or therapeutic biomarkers.

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APA: Copy

Ahmadiany, Mahdieh, Alavi Samani, Mahshid, HASHEMI, ZAHRA, MOOSAVI, MOHAMMAD AMIN, & RAHMATI, MARVEH. (2019). The Increased RNase Activity of IRE1α in PBMCs from Patients with Rheumatoid Arthritis. ADVANCED PHARMACEUTICAL BULLETIN, 9(3), 505-509. SID. https://sid.ir/paper/749463/en

Vancouver: Copy

Ahmadiany Mahdieh, Alavi Samani Mahshid, HASHEMI ZAHRA, MOOSAVI MOHAMMAD AMIN, RAHMATI MARVEH. The Increased RNase Activity of IRE1α in PBMCs from Patients with Rheumatoid Arthritis. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2019;9(3):505-509. Available from: https://sid.ir/paper/749463/en

IEEE: Copy

Mahdieh Ahmadiany, Mahshid Alavi Samani, ZAHRA HASHEMI, MOHAMMAD AMIN MOOSAVI, and MARVEH RAHMATI, “The Increased RNase Activity of IRE1α in PBMCs from Patients with Rheumatoid Arthritis,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 9, no. 3, pp. 505–509, 2019, [Online]. Available: https://sid.ir/paper/749463/en

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