QUANTITATIVE EVALUATION OF HEMODYNAMIC PARAMETERS DURING ACUTE ALVEOLAR HYPOXIA AND HYPERCAPNIA IN THE ISOLATED VENTILATED-PERFUSED RABBIT LUNG

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KETABCHI F.; SHID MOUSAVI SEYED MOSTAFA; WEISSMANN N.; DEHGHAN GH.A.

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Journal: Physiology and Pharmacology Year:2009 | Volume:13 | Issue:2 Page(s): 199-208

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Title

QUANTITATIVE EVALUATION OF HEMODYNAMIC PARAMETERS DURING ACUTE ALVEOLAR HYPOXIA AND HYPERCAPNIA IN THE ISOLATED VENTILATED-PERFUSED RABBIT LUNG

Author(s)

KETABCHI F. | SHID MOUSAVI SEYED MOSTAFA | WEISSMANN N. | DEHGHAN GH.A. | Issue Writer Certificate

Keywords

ISOLATED LUNGQ3

VASCULAR RESISTANCEQ3

HYPOXIAQ3

HYPERCAPNIAQ3

RABBITQ3

Abstract

Introduction: Acute respiratory disorders such as obstructive pulmonary diseases and hypoventilation may lead to alveolar HYPOXIA and HYPERCAPNIA. The effect of these events on the pulmonary vascular beds remains controversial. The aim of this study was to establish an isolated perfused lung setup and investigate the effects of alveolar HYPOXIA and HYPERCAPNIA on pulmonary VASCULAR RESISTANCE.Methods: White New Zealand RABBITs were anaesthetized, heparin was administered as anticoagulant and trachea was cannulated. Then the lung was exposed and perfused with Krebs solution through a pulmonary artery cannula. The ventilated-perfused lung was carefully excised from the chest and the healthy lungs were randomly divided into three groups (n = 7 each group). Ventilation was performed for 30 min with normoxic-normocapnic, hypoxic-normocapnic, or hypoxic-hypercapnic gas mixtures. The percent changes of pulmonary VASCULAR RESISTANCE per min (%PVR) and their maximum values were evaluated.Results: Hypoxic-normocapnic ventilation resulted in an initial sharp rise in PVR that reversed to a slow decline after 8 min of exposure. After 12 min of exposure, a second steady rise in PVR occurred and continued until the end of the experiment. The rate of rise of PVR during hypoxic-hypercapnia was steeper (17.3 ± 2.4% /min) compared to hypoxic-normocapnia (8.86 ± 1.6% /min), but the maximum increases observed in PVR were similar in both conditions.Conclusion: In the isolated ventilated perfused lung, acute alveolar HYPOXIA had a complex influence on PVR and the combination of HYPOXIA with HYPERCAPNIA transiently strengthened PVR without affecting its maximum level.

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APA: Copy

KETABCHI, F., SHID MOUSAVI, SEYED MOSTAFA, WEISSMANN, N., & DEHGHAN, GH.A.. (2009). QUANTITATIVE EVALUATION OF HEMODYNAMIC PARAMETERS DURING ACUTE ALVEOLAR HYPOXIA AND HYPERCAPNIA IN THE ISOLATED VENTILATED-PERFUSED RABBIT LUNG. PHYSIOLOGY AND PHARMACOLOGY, 13(2), 199-208. SID. https://sid.ir/paper/74949/en

Vancouver: Copy

KETABCHI F., SHID MOUSAVI SEYED MOSTAFA, WEISSMANN N., DEHGHAN GH.A.. QUANTITATIVE EVALUATION OF HEMODYNAMIC PARAMETERS DURING ACUTE ALVEOLAR HYPOXIA AND HYPERCAPNIA IN THE ISOLATED VENTILATED-PERFUSED RABBIT LUNG. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2009;13(2):199-208. Available from: https://sid.ir/paper/74949/en

IEEE: Copy

F. KETABCHI, SEYED MOSTAFA SHID MOUSAVI, N. WEISSMANN, and GH.A. DEHGHAN, “QUANTITATIVE EVALUATION OF HEMODYNAMIC PARAMETERS DURING ACUTE ALVEOLAR HYPOXIA AND HYPERCAPNIA IN THE ISOLATED VENTILATED-PERFUSED RABBIT LUNG,” PHYSIOLOGY AND PHARMACOLOGY, vol. 13, no. 2, pp. 199–208, 2009, [Online]. Available: https://sid.ir/paper/74949/en

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