THE ROLE OF NO AND CGMP IN VASODILATORY EFFECT OF β2-ADRENOCEPTORS IN RAT 
SKIN VESSELS

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GOLMOHAMMADI MOJTABA; HAJIZADEH S.; FAGHIHI S.M.; HOSSEINI MARZIEH; ROHAMPOUR K.

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Journal: Physiology and Pharmacology Year:2009 | Volume:13 | Issue:2 Page(s): 151-159

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Title

THE ROLE OF NO AND CGMP IN VASODILATORY EFFECT OF β2-ADRENOCEPTORS IN RAT SKIN VESSELS

Author(s)

Keywords

β2Q3

SANS-SERIF; COLOR: BLACK">-ADRENOCEPTORQ3

SKIN BLOOD FLOWQ3

LASER DOPPLER FLOWMETERYQ3

SALBUTAMOLQ3

RATQ3

Abstract

Introduction: In recent studies, both endothelium-dependent and endothelium-independent mechanisms have been reported for the action of b-adrenoceptors. The aim of this study was to investigate the role of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) in β2-adrenoceptors (b2-AR) mediated vasodilation in RAT skin vessels. Methods: All drugs were injected subcutaneously into the plantar skin of the hind paw. Injection volume was 10 ml (5ml/min). Induction of anesthesia was performed with urethane 1.5 g/kg. LASER DOPPLER FLOWMETERY (LDF) technique was used to monitor the SKIN BLOOD FLOW (SBF).Results: The results obtained in this study showed that different doses of SALBUTAMOL, a selective b2-AR agonist (1mM), caused a significant increase of SBF, but effects induced by different doses of SALBUTAMOL were not significantly different. Atenolol, a selective b1-adrenoceptor antagonist (10 mM), alone and with SALBUTAMOL had no significant effect on SBF. Propranolol, a non selective b-adrenoceptor antagonist (1 mM), did not changed SBF by itself, but significantly reduced the vasodilatory effect of SALBUTAMOL. LNNA, a NO inhibitor (10mM) and methylen blue, a cGMP inhibitor (3mM), caused significant decreases in SBF equal to 6.95% and 7.91%, respectively. SALBUTAMOL injection after LNNA and NO raised the SBF to 24.7% and 22.5%, respectively. These values were significantly lower than the value observed for SALBUTAMOL (42.73%).Conclusion: The results indicated that, SALBUTAMOL dilates RAT skin vessels via b2- ARs. NO and cGMP are involved in b2-ARs mediated vasodilation and contributed to the regulation of skin vascular tone. More studies are required to elucidate the exact mechanism of function of b2-adrenoceptors.

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APA: Copy

GOLMOHAMMADI, MOJTABA, HAJIZADEH, S., FAGHIHI, S.M., HOSSEINI, MARZIEH, & ROHAMPOUR, K.. (2009). THE ROLE OF NO AND CGMP IN VASODILATORY EFFECT OF β₂-ADRENOCEPTORS IN RAT SKIN VESSELS. PHYSIOLOGY AND PHARMACOLOGY, 13(2), 151-159. SID. https://sid.ir/paper/74951/en

Vancouver: Copy

GOLMOHAMMADI MOJTABA, HAJIZADEH S., FAGHIHI S.M., HOSSEINI MARZIEH, ROHAMPOUR K.. THE ROLE OF NO AND CGMP IN VASODILATORY EFFECT OF β₂-ADRENOCEPTORS IN RAT SKIN VESSELS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2009;13(2):151-159. Available from: https://sid.ir/paper/74951/en

IEEE: Copy

MOJTABA GOLMOHAMMADI, S. HAJIZADEH, S.M. FAGHIHI, MARZIEH HOSSEINI, and K. ROHAMPOUR, “THE ROLE OF NO AND CGMP IN VASODILATORY EFFECT OF β₂-ADRENOCEPTORS IN RAT SKIN VESSELS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 13, no. 2, pp. 151–159, 2009, [Online]. Available: https://sid.ir/paper/74951/en

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