LONG-LASTING EFFECTS OF ORAL MORPHINE DEPENDENCE ON SPATIAL LEARNING AND MEMORY IN RATS

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POURMOTEABED A.R.; TOUHIDI A.; NEDAEI S.E.; FARSHCHI B.; PEYVASTEGAN N.; SAMADZADEH SARA

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Journal: Physiology and Pharmacology Year:2007 | Volume:11 | Issue:3 Page(s): 167-173

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Title

LONG-LASTING EFFECTS OF ORAL MORPHINE DEPENDENCE ON SPATIAL LEARNING AND MEMORY IN RATS

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Keywords

ORAL DEPENDENCEQ3

RATQ3

SPATIAL LEARNING AND MEMORYQ3

MORRIS WATER MAZEQ3

Abstract

Introduction: It has been previously reported that oral morphine dependence facilitates formation of SPATIAL LEARNING AND MEMORY in RATs. Therefore, in the current study the long lasting effects of morphine on above mentioned phenomena in with drawn animals were studied.Methods: In present study N-MRI male RATs (250-350 g) received morphine sulfate (0.1- 0.4 mg/m!) (in dependent and withdrawal groups) or sucrose (in control group) in drinking water for 30 consecutive days. MORRIS WATER MAZE (MWM) studies were performed during morphine or sucrose application (in control and dependent animals), or after morphine elimination (in withdrawal groups). SPATIAL LEARNING AND MEMORY parameters were recorded and subjected to the ANOVA.Results: Data showed better acquisition of spatial learning in dependent and withdrawal groups with respect to control animals.Conclusion: Oral morphine dependence has long lasting facilitator effect on acquisition of spatial learning in RATs.

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APA: Copy

POURMOTEABED, A.R., TOUHIDI, A., NEDAEI, S.E., FARSHCHI, B., PEYVASTEGAN, N., & SAMADZADEH, SARA. (2007). LONG-LASTING EFFECTS OF ORAL MORPHINE DEPENDENCE ON SPATIAL LEARNING AND MEMORY IN RATS. PHYSIOLOGY AND PHARMACOLOGY, 11(3), 167-173. SID. https://sid.ir/paper/74957/en

Vancouver: Copy

POURMOTEABED A.R., TOUHIDI A., NEDAEI S.E., FARSHCHI B., PEYVASTEGAN N., SAMADZADEH SARA. LONG-LASTING EFFECTS OF ORAL MORPHINE DEPENDENCE ON SPATIAL LEARNING AND MEMORY IN RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2007;11(3):167-173. Available from: https://sid.ir/paper/74957/en

IEEE: Copy

A.R. POURMOTEABED, A. TOUHIDI, S.E. NEDAEI, B. FARSHCHI, N. PEYVASTEGAN, and SARA SAMADZADEH, “LONG-LASTING EFFECTS OF ORAL MORPHINE DEPENDENCE ON SPATIAL LEARNING AND MEMORY IN RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 11, no. 3, pp. 167–173, 2007, [Online]. Available: https://sid.ir/paper/74957/en

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