Association between CA-125, ESR, and high-sensitive C-reactive protein and cardiac function in hemodialysis patients

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AZDAKI NAHID; SAREMI ZEINAB; Tanaki Zahra

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Journal Paper

Paper Information

Journal: JOURNAL OF RENAL INJURY PREVENTION Year:2018 | Volume:7 | Issue:4 Page(s): 286-291

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Information Journal Paper

Title

Association between CA-125, ESR, and high-sensitive C-reactive protein and cardiac function in hemodialysis patients

Author(s)

AZDAKI NAHID | SAREMI ZEINAB | Tanaki Zahra | Issue Writer Certificate

Keywords

Kidney disease

Heart failure

Hemodialysis

Erythrocyte sedimentation rate

C-reactive protein

CA-125

Abstract

Introduction: Inflammation plays an important role in the pathogenesis of cardiovascular diseases in patients receiving Hemodialysis. Objectives: To compare serum levels of quantitative as high-sensitive C-reactive protein (hs-CRP), Erythrocyte sedimentation rate (ESR), and cancer antigen 125 (CA-125) among three groups including Hemodialysis with Heart failure (HF), Hemodialysis without HF and healthy controls. Patients and Methods: Seventy patients with chronic Kidney disease (CKD) receiving Hemodialysis were included. Thirty-five healthy subjects were in the control group. Inflammatory markers were measured. All subjects underwent 2D transthoracic echocardiography. HF was defined as LVEF (left ventricular ejection fraction) <50%. Results: ESR and hs-CRP levels, but not CA-125, were significantly higher in Hemodialysis group versus control group. Median (IQR) ESR was significantly higher in Hemodialysis group with systolic HF ([16. 50 [17]) and without systolic HF (15. 50 [21]) compared to control group (8 [7]); P < 0. 001. Likewise, median (IQR) hs-CRP was higher in Hemodialysis with HF (9 [3]) and without HF (9 [5]) than in control group (4[2]); P < 0. 001. The Mann-Whitney U tests did not show any statistically significant difference within Hemodialysis group between those with and without HF regarding ESR (P = 0. 81) or hs-CRP (P = 0. 76). However, median (IQR) CA-125 value was significantly higher in Hemodialysis with systolic HF group (23. 20 [25. 04]) compared to Hemodialysis without systolic HF (11. 40 [8. 91]); P = 0. 003. Conclusion: ESR and hs-CRP levels are increased among ESRD patients on Hemodialysis regardless of the presentence of HF. However, CA-125 was the only marker which showed a significant increase in the presence of HF. CA-125 needs further studies to determine its role in follow-up and prognosis of CKD patients with systolic HF.

Cites

Relationship between neutrophil to lymphocyte ratio and mortality and morbidity of dialysis patients in Birjand, a one-year old follow-up: brief report

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APA: Copy

AZDAKI, NAHID, SAREMI, ZEINAB, & Tanaki, Zahra. (2018). Association between CA-125, ESR, and high-sensitive C-reactive protein and cardiac function in hemodialysis patients. JOURNAL OF RENAL INJURY PREVENTION, 7(4), 286-291. SID. https://sid.ir/paper/749679/en

Vancouver: Copy

AZDAKI NAHID, SAREMI ZEINAB, Tanaki Zahra. Association between CA-125, ESR, and high-sensitive C-reactive protein and cardiac function in hemodialysis patients. JOURNAL OF RENAL INJURY PREVENTION[Internet]. 2018;7(4):286-291. Available from: https://sid.ir/paper/749679/en

IEEE: Copy

NAHID AZDAKI, ZEINAB SAREMI, and Zahra Tanaki, “Association between CA-125, ESR, and high-sensitive C-reactive protein and cardiac function in hemodialysis patients,” JOURNAL OF RENAL INJURY PREVENTION, vol. 7, no. 4, pp. 286–291, 2018, [Online]. Available: https://sid.ir/paper/749679/en

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