Promoter Methylation of Four Tumor Suppressor Genes in Human Papillary Thyroid Carcinoma

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KHATAMI FATEMEH; LARIJANI BAGHER; HESHMAT RAMIN; NASIRI SHIRZAD; SAFFAR HIVA; SHAFIEE GITA; Mossafa Azam; TAVANGAR SEYED MOHAMMAD

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Journal: IRANIAN JOURNAL OF PATHOLOGY (IJP) Year:2019 | Volume:14 | Issue:4 Page(s): 290-298

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Title

Promoter Methylation of Four Tumor Suppressor Genes in Human Papillary Thyroid Carcinoma

Author(s)

Keywords

Tumor suppressor genes

Methylation

Papillary thyroid cancers

Abstract

Background & Objective: Papillary thyroid cancer (PTC) is considered to be the most common type of thyroid malignancies. Epigenetic alteration, in which the chromatin conformation and gene expression change without changing the sequence of DNA, can occur in some Tumor suppressor genes and oncogenes. Methylation is the most common type of epigenetic alterations that can be an excellent indicator of PTC invasive behavior. Methods: In this research, we determined the promoter Methylation status of four Tumor suppressor genes (SLC5A8, RASSF1, MGMT, and DNMT1) and compared the results of 55 PTC cases with 40 goiter patients. For Methylation, we used the Methylation-sensitive high resolution melting (MS-HRM) assay technique. The resulting graphs of each run were compared with those of 0%, 50%, and 100% methylated controls. Results: Our data showed that the promoter Methylation of SLC5A8, Ras association domain family member 1(RASSF1), and MGMT were significantly different between PTC tissue and goiter with P-value less than 0. 05. The most significant differences were observed in RASSF1; 77. 2% of hyper-methylated PTC patients versus 15. 6% hyper-methylated goiter samples (P<0. 001). Conclusion: RASSF1 promoter Methylation can be a PTC genetic marker. RASSF1 promoter Methylation is under the impact of the methyltransferase genes (DNMT1 and MGMT), protein expression, and promoter Methylation.

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APA: Copy

KHATAMI, FATEMEH, LARIJANI, BAGHER, HESHMAT, RAMIN, NASIRI, SHIRZAD, SAFFAR, HIVA, SHAFIEE, GITA, Mossafa, Azam, & TAVANGAR, SEYED MOHAMMAD. (2019). Promoter Methylation of Four Tumor Suppressor Genes in Human Papillary Thyroid Carcinoma. IRANIAN JOURNAL OF PATHOLOGY (IJP), 14(4), 290-298. SID. https://sid.ir/paper/749774/en

Vancouver: Copy

KHATAMI FATEMEH, LARIJANI BAGHER, HESHMAT RAMIN, NASIRI SHIRZAD, SAFFAR HIVA, SHAFIEE GITA, Mossafa Azam, TAVANGAR SEYED MOHAMMAD. Promoter Methylation of Four Tumor Suppressor Genes in Human Papillary Thyroid Carcinoma. IRANIAN JOURNAL OF PATHOLOGY (IJP)[Internet]. 2019;14(4):290-298. Available from: https://sid.ir/paper/749774/en

IEEE: Copy

FATEMEH KHATAMI, BAGHER LARIJANI, RAMIN HESHMAT, SHIRZAD NASIRI, HIVA SAFFAR, GITA SHAFIEE, Azam Mossafa, and SEYED MOHAMMAD TAVANGAR, “Promoter Methylation of Four Tumor Suppressor Genes in Human Papillary Thyroid Carcinoma,” IRANIAN JOURNAL OF PATHOLOGY (IJP), vol. 14, no. 4, pp. 290–298, 2019, [Online]. Available: https://sid.ir/paper/749774/en

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