HEXOKINASE BINDING SITES IN MITOCHONDRIA OF NORMAL AND TUMORAL TISSUES OF HUMAN BRAIN

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GOLESTANI A.; NEMAT GORGANI M.

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Journal: Physiology and Pharmacology Year:2002 | Volume:5 | Issue:2 Page(s): 141-152

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Information Journal Paper

Title

HEXOKINASE BINDING SITES IN MITOCHONDRIA OF NORMAL AND TUMORAL TISSUES OF HUMAN BRAIN

Author(s)

GOLESTANI A. | NEMAT GORGANI M. | Issue Writer Certificate

Keywords

HEXOKINASE TYPE IQ4

BINDING SITESQ4

NORMAL AND TUMORAL BRAIN'S MITOCHONDRIAQ4

MONOCLONAL ANTIBODIESQ4

PORINQ4

Abstract

In this study, the interaction of type I hexokinase (HK I) with mitochondria obtained from biopsies of normal and tumoral tissues of human brain was investigated. This effort was undertaken with the aim of exploring possible differences in the mode of association of the enzyme with the outer mitochondrial membrane in the above-mentioned sources. The results showed that the two sites for binding of HK I based on extensive studies carried out on rat brain mitochondria are similarly present in the human brain mitochondria. This was achieved by preparing mitochondria from specified tissues by differential centrifugation technique. The susceptibility of enzyme towards release by G6P and KSCN and its rebinding was then studied using mitochondria of liver and brain tissues. MONOCLONAL ANTIBODIES provided useful tools to compare topological surface changes on mitochondria from various tissues. Differences in the microenvironments of HK binding as reflected by the presented data are suggested to be of importance in regulation of the catalytic potential of the bound enzyme. The real metabolic significance of this association in relation to cancer and its practical importance need further investigation.

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APA: Copy

GOLESTANI, A., & NEMAT GORGANI, M.. (2002). HEXOKINASE BINDING SITES IN MITOCHONDRIA OF NORMAL AND TUMORAL TISSUES OF HUMAN BRAIN. PHYSIOLOGY AND PHARMACOLOGY, 5(2), 141-152. SID. https://sid.ir/paper/74981/en

Vancouver: Copy

GOLESTANI A., NEMAT GORGANI M.. HEXOKINASE BINDING SITES IN MITOCHONDRIA OF NORMAL AND TUMORAL TISSUES OF HUMAN BRAIN. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2002;5(2):141-152. Available from: https://sid.ir/paper/74981/en

IEEE: Copy

A. GOLESTANI, and M. NEMAT GORGANI, “HEXOKINASE BINDING SITES IN MITOCHONDRIA OF NORMAL AND TUMORAL TISSUES OF HUMAN BRAIN,” PHYSIOLOGY AND PHARMACOLOGY, vol. 5, no. 2, pp. 141–152, 2002, [Online]. Available: https://sid.ir/paper/74981/en

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