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Information Journal Paper

Title

Circulating MiR-29a, Possible Use as a Biomarker for Monitoring IgA Nephropathy

Pages

  107-118

Abstract

 Introduction. Previous studies have shown that TGF-β 1/Smad3 signaling promotes renal fibrosis by inhibiting miR-29. To date, only few studies have reportedon circulating microRNAs in IgA nephropathy (IgAN). However, the plasma expression of miR-29a and its role in patients with IgAN remains unclear. In this study, we attempted to elucidate whether plasma miR-29a expression can be used as a biomarker for monitoring disease states. Methods. For this study, 15 healthy subjects, 36 patients with untreated renal biopsy-proven IgAN, and 79 patients with IgAN, who were under treatment for a period of 1 year on an average, all of whom had similar age and gender distributions, were included. The plasma expression of miR-29a in each group was explored by real-time PCR, and the relationship between miR-29a expression and clinical, pathological, and prognostic indicators of IgAN was further evaluated. Results. Relative plasma expression of miR-29a in patients with IgAN was significantly lower than that in healthy controls (P <. 001), and these changes in plasma miR-29a could be suppressed by treatment (P <. 05). Plasma miR-29a was positively correlated with eGFR and negatively correlated with proteinuria and serum creatinine, irrespective of whether or not the patients with IgAN accepted treatment (P <. 05). Plasma miR-29a level was negatively correlated with primary pathological parameters such as crescent formation, Lee’ s and Oxford classification (P <. 05). Kaplan– Meier analysis revealed that patients with high plasma expression of miR-29a had better renal function and better response to treatment compared to those with low expression (P <. 05). Conclusion. Plasma miR-29a could be considered as a biological marker that reflects renal damage and function, to predict the progression of IgAN.

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    APA: Copy

    Dong, Xu, Mo, Zihe, & He, Yongcheng. (2020). Circulating MiR-29a, Possible Use as a Biomarker for Monitoring IgA Nephropathy. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 14(2), 107-118. SID. https://sid.ir/paper/750074/en

    Vancouver: Copy

    Dong Xu, Mo Zihe, He Yongcheng. Circulating MiR-29a, Possible Use as a Biomarker for Monitoring IgA Nephropathy. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2020;14(2):107-118. Available from: https://sid.ir/paper/750074/en

    IEEE: Copy

    Xu Dong, Zihe Mo, and Yongcheng He, “Circulating MiR-29a, Possible Use as a Biomarker for Monitoring IgA Nephropathy,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 14, no. 2, pp. 107–118, 2020, [Online]. Available: https://sid.ir/paper/750074/en

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