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Information Journal Paper

Title

ACUTE DIRECT EFFECTS OF CYCLOSPORINE ON EXTRACELLULAR FIELD POTENTIAL OF ISOLATED RABBIT AV NODE DURING EXPERIMENTAL ATRIAL FIBRILLATION

Pages

  507-516

Abstract

 Introduction: Previous studies have indicated a relationship between MPTP pore and AV nodal rate-dependent properties. The aim of present study was to determine acute direct effects of CYCLOSPORINE on extracellular field potential of isolated rabbit AV node during experimental ATRIAL FIBRILLATION.Methods: In one group of male New Zealand rabbits (1.5-2.5 kg) cumulative concentrations of CYCLOSPORINE (0.5-10mm) were applied on isolated perfused atrio-nodal preparation (n=7). Extracellular field potential recording was sampled during specific stimulation protocols (recovery, zone of concealment and ATRIAL FIBRILLATION) in the presence of drug on electrophysiological properties of AV-node.Results: CYCLOSPORINE significantly decreased the ventricular rate (HH mean) from 231.8±5.7 to 277.4±14.6 msec and functional refractory period during AF (AF FRP) from 138.3±7.5 to 161.2±10.31 msec in control and treated groups, respectively. Effective refractory period during AF (AF ERP) was significantly decreased by CYCLOSPORINE 10 mM compared to control group (p<0.05).Conclusion: CYCLOSPORINE-evoked slowing ventricular heart rate during AF was induced by increasing functional refractoy period and ZOC. A possible mechanism can be through blocking of MPT pores.

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    APA: Copy

    KHORI, VAHID, SHARIATNEZHAD, SEPIDEH, ALIZADEH, ALI MOHAMMAD, YAZDI, HAMIDREZA, POURABOUK, MONA, BADAGHABADI, FAKHRI, RAJAEI, MARYAM, MOHEIMANI, HAMIDREZA, NAYEBPOUR, MOHSEN, & SALEKI, SAEED. (2012). ACUTE DIRECT EFFECTS OF CYCLOSPORINE ON EXTRACELLULAR FIELD POTENTIAL OF ISOLATED RABBIT AV NODE DURING EXPERIMENTAL ATRIAL FIBRILLATION. PHYSIOLOGY AND PHARMACOLOGY, 15(4), 507-516. SID. https://sid.ir/paper/75037/en

    Vancouver: Copy

    KHORI VAHID, SHARIATNEZHAD SEPIDEH, ALIZADEH ALI MOHAMMAD, YAZDI HAMIDREZA, POURABOUK MONA, BADAGHABADI FAKHRI, RAJAEI MARYAM, MOHEIMANI HAMIDREZA, NAYEBPOUR MOHSEN, SALEKI SAEED. ACUTE DIRECT EFFECTS OF CYCLOSPORINE ON EXTRACELLULAR FIELD POTENTIAL OF ISOLATED RABBIT AV NODE DURING EXPERIMENTAL ATRIAL FIBRILLATION. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2012;15(4):507-516. Available from: https://sid.ir/paper/75037/en

    IEEE: Copy

    VAHID KHORI, SEPIDEH SHARIATNEZHAD, ALI MOHAMMAD ALIZADEH, HAMIDREZA YAZDI, MONA POURABOUK, FAKHRI BADAGHABADI, MARYAM RAJAEI, HAMIDREZA MOHEIMANI, MOHSEN NAYEBPOUR, and SAEED SALEKI, “ACUTE DIRECT EFFECTS OF CYCLOSPORINE ON EXTRACELLULAR FIELD POTENTIAL OF ISOLATED RABBIT AV NODE DURING EXPERIMENTAL ATRIAL FIBRILLATION,” PHYSIOLOGY AND PHARMACOLOGY, vol. 15, no. 4, pp. 507–516, 2012, [Online]. Available: https://sid.ir/paper/75037/en

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