The Eﬀ ects of Active Ingredients of Barberry Root (Berberine) on Glycemic Control and Insulin Resistance in Type 2 Diabetic Patients

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RASHIDI HOMEIRA; NAMJOYAN FOROOGH; MEHRABAN ZAHRA; ZAKERKISH MEHRNOOSH; GHADERIAN Seyed Bahman; LATIFI SEYED MAHMOUD

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Journal: Jundishapur Journal of Natural Pharmaceutical Products Year:2018 | Volume:13 | Issue:1 Page(s): 0-0

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Title

The Eﬀ ects of Active Ingredients of Barberry Root (Berberine) on Glycemic Control and Insulin Resistance in Type 2 Diabetic Patients

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Keywords

Type 2 Diabetes Berberine (Berberine)

Barberry (Berberis.Vulgaris)

Fructosamine

Abstract

Background: Diabetes mellitus is one of the most common metabolic diseases in the world. Recently, willingness to use alternative treatments to control and reduce blood sugar levels has noticeably increased. The general objective of this study is to investigate the hypoglycemic eﬀ ect of the active ingredient of Berberis (Berberine) in patients with type 2 diabetes. Methods: In this double-blind randomized controlled placebo trial, 84 patients with type 2 diabetes were evaluated. The patients were divided in 2 groups (42 each). In addition to their previous drugs, new diet, and life style each group received Berberine capsules 500 mg or placebo twice daily for 4 weeks. At baseline, weight, height, blood pressure, and BMI were calculated for all patients. Fasting plasma glucose, post-meal plasma glucose, Fructosamine, lipid proﬁ le, fasting blood insulin levels, BUN, creatinine, and liver enzymes were taken from all patients before the study and after 4 weeks. HOMA-IR and HOMA- % were calculated. Results: After administration of Berberine for a month, average blood sugar (FBS) in the Berberine group decreased from 192 59. 6 to 167. 7 51. 8, which was statistically signiﬁ cant compared with the results of the placebo group (P = 0. 036). There was a signiﬁ cant decrease from 266. 1 93. 7 mg dl to 222. 5 76 in 2HPP in the Berberine group compared with the placebo group (P = 0. 001). There was also a signiﬁ cant decrease from 425. 7 139. 7 micromoles per liter to 344. 9 126. 1 micromoles per liter in fructoseamine in the Berberine group compared with the placebo group (P = 0. 014). In addition, fasting insulin, HOMA- %, and HOMA-IR increased in the Berberine group compared with the placebo group, however, this increase was not statistically signiﬁ cant. There was a signiﬁ cant decrease in LDL, TG, VLDL in the Berberine group, however, it was not lower than that in the placebo group. Also, total cholesterol in the Berberine group decreased insigniﬁ cantly compared to the placebo group. There was no signiﬁ cant diﬀ erence between the 2 groups in terms of BMI, systolic, and diastolic blood pressure. Conclusions: The results showed taking Berberine in patients with type 2 diabetes for 1 month signiﬁ cantly reduces the fasting plasma glucose, post-meal blood glucose, and Fructosamine. No signiﬁ cation changes were found in lipid proﬁ les, fasting insulin, HOMA-IR, and HOMA- %.

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APA: Copy

RASHIDI, HOMEIRA, NAMJOYAN, FOROOGH, MEHRABAN, ZAHRA, ZAKERKISH, MEHRNOOSH, GHADERIAN, Seyed Bahman, & LATIFI, SEYED MAHMOUD. (2018). The Eﬀ ects of Active Ingredients of Barberry Root (Berberine) on Glycemic Control and Insulin Resistance in Type 2 Diabetic Patients. JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS, 13(1), 0-0. SID. https://sid.ir/paper/750491/en

Vancouver: Copy

RASHIDI HOMEIRA, NAMJOYAN FOROOGH, MEHRABAN ZAHRA, ZAKERKISH MEHRNOOSH, GHADERIAN Seyed Bahman, LATIFI SEYED MAHMOUD. The Eﬀ ects of Active Ingredients of Barberry Root (Berberine) on Glycemic Control and Insulin Resistance in Type 2 Diabetic Patients. JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS[Internet]. 2018;13(1):0-0. Available from: https://sid.ir/paper/750491/en

IEEE: Copy

HOMEIRA RASHIDI, FOROOGH NAMJOYAN, ZAHRA MEHRABAN, MEHRNOOSH ZAKERKISH, Seyed Bahman GHADERIAN, and SEYED MAHMOUD LATIFI, “The Eﬀ ects of Active Ingredients of Barberry Root (Berberine) on Glycemic Control and Insulin Resistance in Type 2 Diabetic Patients,” JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS, vol. 13, no. 1, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/750491/en

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