NEW MANIFESTATIONS OF ELECTROPHYSIOLOGICAL REMODELING OF HEART DURING EXPERIMENTAL MODEL OF ATRIAL FIBRILLATION IN CIRRHOTIC RAT ISOLATED HEART

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KHORI VAHID; ALIZADEH ALI MOHAMMAD; MOHEIMANI HAMIDREZA; SHAKIBA DELARAM; AMINOLSHARIEH NAJAFI SOROOSH; ALIZADEH SHAHRYAR; AMIRIYANI TAGHI; BANIKARIMI ARDESHIR; ZAHEDI MAHDI; MOLSEGHI MOHAMAD HADI; DEHPOUR AHMAD REZA

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Physiology and Pharmacology Year:2013 | Volume:17 | Issue:1 Page(s): 61-71

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,154

Download:

Cites:

Information Journal Paper

Title

NEW MANIFESTATIONS OF ELECTROPHYSIOLOGICAL REMODELING OF HEART DURING EXPERIMENTAL MODEL OF ATRIAL FIBRILLATION IN CIRRHOTIC RAT ISOLATED HEART

Author(s)

Keywords

CIRRHOSISQ3

ATRIAL FIBRILLATIONQ2

ATRIOVENTRICULAR NODEQ2

Abstract

Introduction: The present study is aimed to evaluate electrophysiological remodeling of atrioventricular (AV) node and ventricular conduction during experimental ATRIAL FIBRILLATION (AF) model in isolated heart of cirrhotic rats.Methods: CIRRHOSIS-induced electrophysiological remodeling was evaluated in 24 isolated retrogradely perfused rat hearts in 2 groups (control and cirrhotic). CIRRHOSIS was induced after 6 weeks of common bile duct ligation in rats.Extracellular filed potential was recorded from upper atrium and right ventricle. The conduction time, refractoriness and frequency-dependent properties of AV node were characterized by specific stimulation protocols. Experimental AF was simulated by high-rate atrial pacing with random coupling intervals (range 75-125 ms).Results: Nodal conduction time and ventricular responsiveness were significantly increased in the cirrhotic rats compared to the control (95.8±4.2 ms vs.78.8±3.3 ms) (P<0.05). Nodal protective function during AF was potentiated with increased R-R interval, concealed beats, ventricular refractoriness and zone of concealment in the cirrhotic group. CIRRHOSIS evoked rate-dependent ventricular conduction time shortening with different patterns during arrhythmia.Conclusion: CIRRHOSIS-induced electrophysiological remodeling was shown by increased AV nodal conduction and shortened ventricular conduction. This electrophysiological remodeling may be considered as a new manifestation of cirrhotic cardiomyopathy in the heart, which can change ventricular rhythm during arrhythmia.

Cites

No record.

References

No record.

Cite

APA: Copy

KHORI, VAHID, ALIZADEH, ALI MOHAMMAD, MOHEIMANI, HAMIDREZA, SHAKIBA, DELARAM, AMINOLSHARIEH NAJAFI, SOROOSH, ALIZADEH, SHAHRYAR, AMIRIYANI, TAGHI, BANIKARIMI, ARDESHIR, ZAHEDI, MAHDI, MOLSEGHI, MOHAMAD HADI, & DEHPOUR, AHMAD REZA. (2013). NEW MANIFESTATIONS OF ELECTROPHYSIOLOGICAL REMODELING OF HEART DURING EXPERIMENTAL MODEL OF ATRIAL FIBRILLATION IN CIRRHOTIC RAT ISOLATED HEART. PHYSIOLOGY AND PHARMACOLOGY, 17(1), 61-71. SID. https://sid.ir/paper/75052/en

Vancouver: Copy

KHORI VAHID, ALIZADEH ALI MOHAMMAD, MOHEIMANI HAMIDREZA, SHAKIBA DELARAM, AMINOLSHARIEH NAJAFI SOROOSH, ALIZADEH SHAHRYAR, AMIRIYANI TAGHI, BANIKARIMI ARDESHIR, ZAHEDI MAHDI, MOLSEGHI MOHAMAD HADI, DEHPOUR AHMAD REZA. NEW MANIFESTATIONS OF ELECTROPHYSIOLOGICAL REMODELING OF HEART DURING EXPERIMENTAL MODEL OF ATRIAL FIBRILLATION IN CIRRHOTIC RAT ISOLATED HEART. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2013;17(1):61-71. Available from: https://sid.ir/paper/75052/en

IEEE: Copy

VAHID KHORI, ALI MOHAMMAD ALIZADEH, HAMIDREZA MOHEIMANI, DELARAM SHAKIBA, SOROOSH AMINOLSHARIEH NAJAFI, SHAHRYAR ALIZADEH, TAGHI AMIRIYANI, ARDESHIR BANIKARIMI, MAHDI ZAHEDI, MOHAMAD HADI MOLSEGHI, and AHMAD REZA DEHPOUR, “NEW MANIFESTATIONS OF ELECTROPHYSIOLOGICAL REMODELING OF HEART DURING EXPERIMENTAL MODEL OF ATRIAL FIBRILLATION IN CIRRHOTIC RAT ISOLATED HEART,” PHYSIOLOGY AND PHARMACOLOGY, vol. 17, no. 1, pp. 61–71, 2013, [Online]. Available: https://sid.ir/paper/75052/en

Related Journal Papers