STUDY OF INTERACTION BETWEEN OPIOID AND A-2 ADRENERGIC SYSTEMS IN ANALGESIC EFFECT OF OXYTOCIN IN LOCUS COERULEUS NUCLEUS

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HAGHIGHI N.; KESMATI M.; FATHI MOGHADAM H.

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Journal: Physiology and Pharmacology Year:2006 | Volume:10 | Issue:3 Page(s): 259-265

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Information Journal Paper

Title

STUDY OF INTERACTION BETWEEN OPIOID AND A-2 ADRENERGIC SYSTEMS IN ANALGESIC EFFECT OF OXYTOCIN IN LOCUS COERULEUS NUCLEUS

Author(s)

HAGHIGHI N. | KESMATI M. | FATHI MOGHADAM H. | Issue Writer Certificate

Keywords

OXYTOCINQ3

PAINQ2

YOHEMBINEQ3

NALOXONEQ3

LOCUS COERULEUS NUCLEUSQ3

Abstract

Introduction: OXYTOCIN is a active neuropeptide of central nervous system. In this study the effects of NALOXONE (opioid receptor antagonist) and yohimbine (a-2 adrenergic receptor antagonist) on analgesic effect of OXYTOCIN applied into the locus coeruleus (LC) nucleus were investigated.Methods: Adult male Wistar rats were used. Animals divided into different groups receiving saline, OXYTOCIN (3 nmol / 2ml), NALOXONE (3 nmol / 2ml) + OXYTOCIN, yohimbine (3 nmol / 2ml) + OXYTOCIN, and NALOXONE + yohimbine + OXYTOCIN. Hot-plate and tail-flick tests were used to evaluate PAIN threshold.Results: Data showed that the injection of OXYTOCIN into the LC nucleus increases the response time to thermal stimulations in both tail flick and hot plate tests. Injection of NALOXONE and yohimbine either separately and or in combination inhibite the antinociception effect of OXYTOCIN.Conclusion: It seems that OXYTOCIN induces its inhibitory effect on acute PAIN via LC nucleus. This effect is probably mediated by the combination of opioid and a-2 adrenergic systems.

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References

ANALGESIC EFFECT OF AQUEOUS SATUREJA HORTENSIS L. SEED EXTRACT IN MALE RAT

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APA: Copy

HAGHIGHI, N., KESMATI, M., & FATHI MOGHADAM, H.. (2006). STUDY OF INTERACTION BETWEEN OPIOID AND A-2 ADRENERGIC SYSTEMS IN ANALGESIC EFFECT OF OXYTOCIN IN LOCUS COERULEUS NUCLEUS. PHYSIOLOGY AND PHARMACOLOGY, 10(3), 259-265. SID. https://sid.ir/paper/75070/en

Vancouver: Copy

HAGHIGHI N., KESMATI M., FATHI MOGHADAM H.. STUDY OF INTERACTION BETWEEN OPIOID AND A-2 ADRENERGIC SYSTEMS IN ANALGESIC EFFECT OF OXYTOCIN IN LOCUS COERULEUS NUCLEUS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2006;10(3):259-265. Available from: https://sid.ir/paper/75070/en

IEEE: Copy

N. HAGHIGHI, M. KESMATI, and H. FATHI MOGHADAM, “STUDY OF INTERACTION BETWEEN OPIOID AND A-2 ADRENERGIC SYSTEMS IN ANALGESIC EFFECT OF OXYTOCIN IN LOCUS COERULEUS NUCLEUS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 10, no. 3, pp. 259–265, 2006, [Online]. Available: https://sid.ir/paper/75070/en

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