THE MODULATORY EFFECTS OF OREXIN B ON THE CALCIUM CHANNELS ACTIVITY IN NEURONAL CELLS OF HELIX ASPERSA (GARDEN SNAIL)

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RASTEGAR FARAJZADEH A.; JANAHMADI M.; FATH ELAHI Y.

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Journal: Physiology and Pharmacology Year:2006 | Volume:10 | Issue:3 Page(s): 191-200

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Title

THE MODULATORY EFFECTS OF OREXIN B ON THE CALCIUM CHANNELS ACTIVITY IN NEURONAL CELLS OF HELIX ASPERSA (GARDEN SNAIL)

Author(s)

RASTEGAR FARAJZADEH A. | JANAHMADI M. | FATH ELAHI Y. | Issue Writer Certificate

Keywords

OREXIN-BQ3

PERTUSSIS TOXINQ3

CALCIUM SPIKEQ3

NEURONAL EXCITABILITYQ3

SNAILQ3

ELECTROPHYSIOLOGYQ3

Abstract

Introduction: The functional effects of OREXIN-B on the CALCIUM SPIKEs and excitability of the neuronal soma membrane of garden SNAIL, Helix aspersa were studied.Methods: Conventional intracellular recording, under the current clamp conditions was performed to examine the effects of OREXIN-B on the configuration and electrophysiological properties of CALCIUM SPIKEs.Results: Application of OREXIN-B (300 nM) led to a membrane depolarization and thereby the increase in excitability of neurons. It also decreased the duration and the amplitude of CALCIUM SPIKEs. On the other hand, OREXIN-B had a dual effect on the amplitude of afterhyper polarization (AHP) in a time dependent manner. The maximum reduction of the amplitude of AHP was recorded within 10 min of OREXIN-B exposure. However a maximum increase in AHP amplitude was observed later (15 min after exposure to OREXIN-B). Inactivation of G-proteins by PERTUSSIS TOXIN (100 nM) was used to test the involvement of Gi/Go in the OREXIN-B induced modulation of calcium channels. Pre-incubation of ganglia for 3-6 h with PTX blocked the depolarization effect of OREXIN-B on the resting membrane potential. OREXIN-B on pretreated neuronal cells with PTX did not statistically change the CALCIUM SPIKE parameters, unless the peak amplitude of AHP increased remarkably.Conclusion: In conclusion, these data suggest that OREXIN-B (300 nM) may affect the membrane excitability and modulates the activity of calcium and calcium activated potassium channels in SNAIL neurons.

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APA: Copy

RASTEGAR FARAJZADEH, A., JANAHMADI, M., & FATH ELAHI, Y.. (2006). THE MODULATORY EFFECTS OF OREXIN B ON THE CALCIUM CHANNELS ACTIVITY IN NEURONAL CELLS OF HELIX ASPERSA (GARDEN SNAIL). PHYSIOLOGY AND PHARMACOLOGY, 10(3), 191-200. SID. https://sid.ir/paper/75074/en

Vancouver: Copy

RASTEGAR FARAJZADEH A., JANAHMADI M., FATH ELAHI Y.. THE MODULATORY EFFECTS OF OREXIN B ON THE CALCIUM CHANNELS ACTIVITY IN NEURONAL CELLS OF HELIX ASPERSA (GARDEN SNAIL). PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2006;10(3):191-200. Available from: https://sid.ir/paper/75074/en

IEEE: Copy

A. RASTEGAR FARAJZADEH, M. JANAHMADI, and Y. FATH ELAHI, “THE MODULATORY EFFECTS OF OREXIN B ON THE CALCIUM CHANNELS ACTIVITY IN NEURONAL CELLS OF HELIX ASPERSA (GARDEN SNAIL),” PHYSIOLOGY AND PHARMACOLOGY, vol. 10, no. 3, pp. 191–200, 2006, [Online]. Available: https://sid.ir/paper/75074/en

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