THE EFFECT OF SHEEP ATRIAL EXTRACT ON BLOOD PRESSURE AND HEMATOCRIT IN RAT

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RANJBAR AFSANEH; NEMATBAKHSH M.

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Journal: Physiology and Pharmacology Year:2003 | Volume:6 | Issue:2 Page(s): 191-198

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Information Journal Paper

Title

THE EFFECT OF SHEEP ATRIAL EXTRACT ON BLOOD PRESSURE AND HEMATOCRIT IN RAT

Author(s)

RANJBAR AFSANEH | NEMATBAKHSH M. | Issue Writer Certificate

Keywords

ANPQ3

SHEEP ATRIAL EXTRACTQ4

HEMATOCRITQ3

ARTERIAL BLOOD PRESSUREQ4

Abstract

Atrial natriuretic peptide (ANP) is a 28 amino acid hormone secreted by atrial myocytes in response to local wall stretch. The effects of this hormone on target tissues (kidney, adrenal gland and smooth muscle) include the regulation of sodium, potassium, blood volume and blood pressure. In the present study, ANP extracted from sheep atria was used and its physiological effects were investigated. For this purpose, 40 g of sheep atrial tissue was homogenized at 40 °C in a buffered solution containing protease inhibitor substance. Homogenized tissue was centrifuged at 2500g for 10 minutes and the supernatant boiled for 10 minutes, then centrifuged again in 10000g. The results -indicated that after i.p. injection of SHEEP ATRIAL EXTRACT to the experimental animals, the level of HEMATOCRIT increased (P<0.005) (This is probably through renal excretion of salt and water). Furthermore, injection of SHEEP ATRIAL EXTRACT produced a decrease in blood pressure (P<0.05). In this respect, the maximum effect was observed after 25 minutes. The fall in blood pressure was also as a result of ANP direct effects on smooth muscles of the blood vessels as well as inhibition of the renin-angiotensin system. Following 25 and 35 minutes, hypertension developed (This is as a result of the interactions among blood pressure control systems). This was followed by another decreases in blood pressure after 45 minutes, probably due to increased renal tubular excretion of salt and water).

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APA: Copy

RANJBAR, AFSANEH, & NEMATBAKHSH, M.. (2003). THE EFFECT OF SHEEP ATRIAL EXTRACT ON BLOOD PRESSURE AND HEMATOCRIT IN RAT. PHYSIOLOGY AND PHARMACOLOGY, 6(2), 191-198. SID. https://sid.ir/paper/75103/en

Vancouver: Copy

RANJBAR AFSANEH, NEMATBAKHSH M.. THE EFFECT OF SHEEP ATRIAL EXTRACT ON BLOOD PRESSURE AND HEMATOCRIT IN RAT. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2003;6(2):191-198. Available from: https://sid.ir/paper/75103/en

IEEE: Copy

AFSANEH RANJBAR, and M. NEMATBAKHSH, “THE EFFECT OF SHEEP ATRIAL EXTRACT ON BLOOD PRESSURE AND HEMATOCRIT IN RAT,” PHYSIOLOGY AND PHARMACOLOGY, vol. 6, no. 2, pp. 191–198, 2003, [Online]. Available: https://sid.ir/paper/75103/en

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