Analysis of NSP4 Gene and Its Association with Genotyping of Rotavirus Group A in Stool Samples

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TEIMOORI ALI; Nejati Mehrab; Ebrahimi Saeedeh; MAKVANDI MANOOCHEHR; Zandi Milad; AZARAN AZARAKHSH

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Journal Paper

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Journal: Iranian Biomedical Journal Year:2018 | Volume:22 | Issue:1 Page(s): 42-49

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Title

Analysis of NSP4 Gene and Its Association with Genotyping of Rotavirus Group A in Stool Samples

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Keywords

NSP4

Rotavirus

Genotyping

Abstract

Background: Non-structural protein 4 (NSP4) is a critical protein for Rotavirus (RV) replication and assembly. This protein has multiple domains and motifs that predispose its function and activity. NSP4 has a sequence divergence in human and animal RVs. Recently, 14 genotypes (E1-E14) of NSP4 have been identified, and E1 and E2 have been shown to be the most common genotypes in human. Methods: The gene and protein sequence of NSP4 in RV-positive samples were inspected with the aim of NSP4 Genotyping and variation analysis in viroporin and other domains. P and G typings of RV samples were carried out by WHO primers using a semi-multiplex PCR method. Non-typeable RV samples were amplified by conserved primers and sequenced. Results: In viroporin and enterotoxin, conserved sequence was detected, and amino acids substitution with the same biochemical properties was found. Conclusion: Association of NSP4 genotype with P or G Genotyping G1/G9 correlates with E1 genogroups. In electrophoretyping of RV, E2 genotype had a short pattern when compared to E1.

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APA: Copy

TEIMOORI, ALI, Nejati, Mehrab, Ebrahimi, Saeedeh, MAKVANDI, MANOOCHEHR, Zandi, Milad, & AZARAN, AZARAKHSH. (2018). Analysis of NSP4 Gene and Its Association with Genotyping of Rotavirus Group A in Stool Samples. IRANIAN BIOMEDICAL JOURNAL, 22(1), 42-49. SID. https://sid.ir/paper/751038/en

Vancouver: Copy

TEIMOORI ALI, Nejati Mehrab, Ebrahimi Saeedeh, MAKVANDI MANOOCHEHR, Zandi Milad, AZARAN AZARAKHSH. Analysis of NSP4 Gene and Its Association with Genotyping of Rotavirus Group A in Stool Samples. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2018;22(1):42-49. Available from: https://sid.ir/paper/751038/en

IEEE: Copy

ALI TEIMOORI, Mehrab Nejati, Saeedeh Ebrahimi, MANOOCHEHR MAKVANDI, Milad Zandi, and AZARAKHSH AZARAN, “Analysis of NSP4 Gene and Its Association with Genotyping of Rotavirus Group A in Stool Samples,” IRANIAN BIOMEDICAL JOURNAL, vol. 22, no. 1, pp. 42–49, 2018, [Online]. Available: https://sid.ir/paper/751038/en

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