THE ROLE OF TISSUE AND CIRCULATORY ANGIOTENSIN CONVERTING ENZYME (ACE) IN THE DEVELOPMENT OF RENOVASCULAR HYPERTENSION IN RAT

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SHARIFI A.M; AKBARLOU N.

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Journal: Physiology and Pharmacology Year:2003 | Volume:6 | Issue:2 Page(s): 173-182

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Title

THE ROLE OF TISSUE AND CIRCULATORY ANGIOTENSIN CONVERTING ENZYME (ACE) IN THE DEVELOPMENT OF RENOVASCULAR HYPERTENSION IN RAT

Author(s)

SHARIFI A.M | AKBARLOU N. | Issue Writer Certificate

Keywords

ANGIOTENSIN CONVERTING ENZYMEQ4

HYPERTENSIONQ4

RENOVASCULARQ4

RATQ4

Abstract

In the present study the correlation between the development of HYPERTENSION and local (including aorta, heart, kidney, lung) as well as circulatory (serum) ACE activity in two kidney, one clip (2 Kl C) RENOVASCULAR model of HYPERTENSION was investigated.For this purpose, left renal artery clipping were performed on 10- to 12-weeks old RATs. Experiments were carried out in 2, 4, 8, and 12 weeks after surgery (2W, 4W, 8W and 12W). After sacrificing, animal's blood sample and tissues including heart, aorta, lung and kidney were dissected out and homogenized in Trizma buffer. ACE activity was determined by hydrolysis of the synthetic substrate, Hip-His-Leu and the amount of hippuric acid released from the substrate were analyzed by HPLC. The results showed that the systolic blood pressure (SBP) was gradually increased in 2 Kl C animals and was markedly higher as compared to that of controls. The ACE activity in all tissues from 2 Kl C was significantly different in all groups. The serum ACE activity of 2 KIC animals was markedly increased in 2W and 4W and reached to a plateau in 8W and 12W groups. These results indicated that there is a positive correlation between augmentation of blood pressure and local ACE activity in various tissues as well as serum, highlighting the significant contribution of local ACE activity as compared to its circulatory one in the development of RENOVASCULAR HYPERTENSION.

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APA: Copy

SHARIFI, A.M, & AKBARLOU, N.. (2003). THE ROLE OF TISSUE AND CIRCULATORY ANGIOTENSIN CONVERTING ENZYME (ACE) IN THE DEVELOPMENT OF RENOVASCULAR HYPERTENSION IN RAT. PHYSIOLOGY AND PHARMACOLOGY, 6(2), 173-182. SID. https://sid.ir/paper/75107/en

Vancouver: Copy

SHARIFI A.M, AKBARLOU N.. THE ROLE OF TISSUE AND CIRCULATORY ANGIOTENSIN CONVERTING ENZYME (ACE) IN THE DEVELOPMENT OF RENOVASCULAR HYPERTENSION IN RAT. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2003;6(2):173-182. Available from: https://sid.ir/paper/75107/en

IEEE: Copy

A.M SHARIFI, and N. AKBARLOU, “THE ROLE OF TISSUE AND CIRCULATORY ANGIOTENSIN CONVERTING ENZYME (ACE) IN THE DEVELOPMENT OF RENOVASCULAR HYPERTENSION IN RAT,” PHYSIOLOGY AND PHARMACOLOGY, vol. 6, no. 2, pp. 173–182, 2003, [Online]. Available: https://sid.ir/paper/75107/en

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